TY - JOUR
T1 - Prognosis evaluation in alpha-fetoprotein negative hepatocellular carcinoma after hepatectomy
T2 - Comparison of five staging systems
AU - Zhang, X. F.
AU - Qi, X.
AU - Meng, B.
AU - Liu, C.
AU - Yu, L.
AU - Wang, B.
AU - Lv, Y.
PY - 2010/8
Y1 - 2010/8
N2 - Aims: Alpha-fetoprotein (AFP) loses its potentials in treatment evaluation and prognosis prediction in patients with AFP negative (≤20 ng/ml) hepatocellular carcinoma (HCC). The present study was to identify the risk factors affecting postoperative survival of AFP negative patients and to determine the optimal staging system in predicting the survival of these patients. Methods: The data of 306 in total and 98 AFP negative patients amongst were retrospectively reviewed. The risk factors affecting survivals of the patients were identified. And various staging systems were compared, including the sixth tumor node metastasis (TNM) system, Okuda staging, Cancer of the Liver Italian Program (CLIP) score, the Barcelona Clinic Liver Cancer (BCLC) staging system, and the Japan Integrated Staging (JIS) score. Results: AFP negative patients tended to have intact tumor capsule and earlier staged tumor by TNM, CLIP and BCLC. The independent risk factors worsening overall survival of AFP negative patients were absence of tumor capsule, Child-Pugh classification B, hepatitis B surface antigen positive and BCLC stage B-C. The risk factors promoting tumor recurrence were tumor size of >3 cm, distribution in two lobes, Okuda stage B-C and BCLC stage B-C. Conclusion: Normal AFP level implies earlier staged tumors. BCLC has the strongest potential in prognosis evaluation in AFP negative patients.
AB - Aims: Alpha-fetoprotein (AFP) loses its potentials in treatment evaluation and prognosis prediction in patients with AFP negative (≤20 ng/ml) hepatocellular carcinoma (HCC). The present study was to identify the risk factors affecting postoperative survival of AFP negative patients and to determine the optimal staging system in predicting the survival of these patients. Methods: The data of 306 in total and 98 AFP negative patients amongst were retrospectively reviewed. The risk factors affecting survivals of the patients were identified. And various staging systems were compared, including the sixth tumor node metastasis (TNM) system, Okuda staging, Cancer of the Liver Italian Program (CLIP) score, the Barcelona Clinic Liver Cancer (BCLC) staging system, and the Japan Integrated Staging (JIS) score. Results: AFP negative patients tended to have intact tumor capsule and earlier staged tumor by TNM, CLIP and BCLC. The independent risk factors worsening overall survival of AFP negative patients were absence of tumor capsule, Child-Pugh classification B, hepatitis B surface antigen positive and BCLC stage B-C. The risk factors promoting tumor recurrence were tumor size of >3 cm, distribution in two lobes, Okuda stage B-C and BCLC stage B-C. Conclusion: Normal AFP level implies earlier staged tumors. BCLC has the strongest potential in prognosis evaluation in AFP negative patients.
KW - Alpha-fetoprotein
KW - Hepatocellular carcinoma
KW - Prognosis
KW - Staging system
KW - Surgery
UR - https://www.scopus.com/pages/publications/77954904529
U2 - 10.1016/j.ejso.2010.05.022
DO - 10.1016/j.ejso.2010.05.022
M3 - 文章
C2 - 20538423
AN - SCOPUS:77954904529
SN - 0748-7983
VL - 36
SP - 718
EP - 724
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
IS - 8
ER -
