Potential of siRNA-albumin complex against cancer

Na Liu; Yan Hua Qi; Chuan Tao Cheng; Wen Bin Yang; Anshoo Malhotra; Qi Zhou

doi:10.1016/j.cbi.2018.04.028

Potential of siRNA-albumin complex against cancer

Na Liu
, Yan Hua Qi
, Chuan Tao Cheng
, Wen Bin Yang
, Anshoo Malhotra
, Qi Zhou

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

RNA interference is a highly specific as well as efficient technology for gene therapy application in molecular oncology. The present study was planned to develop an efficient and stable tumor selective delivery mechanism for siRNA gene therapy for the purpose of both diagnosis as well as therapy. We have used 20 Male wistar rats for the formation of colon cancer model and utilized albumin as carrier molecule for the delivery of siRNA against vascular endothelial growth factor receptor 2 (VEGF R2). The study results confirmed efficient delivery of siRNA at tumor site as confirmed by tagging of siRNA-albumin complex with ^99mTC. Moreover, the expression of VEGF also showed decline after efficient delivery of siRNA at tumor site. The study concluded that albumin is an efficient molecule for the efficient delivery of siRNA at tumor sites.

Original language	English
Pages (from-to)	93-96
Number of pages	4
Journal	Chemico-Biological Interactions
Volume	295
DOIs	https://doi.org/10.1016/j.cbi.2018.04.028
State	Published - 1 Nov 2018
Externally published	Yes

Keywords

Albumin
Colon cancer
Tc
siRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cbi.2018.04.028

Cite this

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title = "Potential of siRNA-albumin complex against cancer",

abstract = "RNA interference is a highly specific as well as efficient technology for gene therapy application in molecular oncology. The present study was planned to develop an efficient and stable tumor selective delivery mechanism for siRNA gene therapy for the purpose of both diagnosis as well as therapy. We have used 20 Male wistar rats for the formation of colon cancer model and utilized albumin as carrier molecule for the delivery of siRNA against vascular endothelial growth factor receptor 2 (VEGF R2). The study results confirmed efficient delivery of siRNA at tumor site as confirmed by tagging of siRNA-albumin complex with 99mTC. Moreover, the expression of VEGF also showed decline after efficient delivery of siRNA at tumor site. The study concluded that albumin is an efficient molecule for the efficient delivery of siRNA at tumor sites.",

keywords = "Albumin, Colon cancer, Tc, siRNA",

author = "Na Liu and Qi, \{Yan Hua\} and Cheng, \{Chuan Tao\} and Yang, \{Wen Bin\} and Anshoo Malhotra and Qi Zhou",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2018",

month = nov,

day = "1",

doi = "10.1016/j.cbi.2018.04.028",

language = "英语",

volume = "295",

pages = "93--96",

journal = "Chemico-Biological Interactions",

issn = "0009-2797",

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}

TY - JOUR

T1 - Potential of siRNA-albumin complex against cancer

AU - Liu, Na

AU - Qi, Yan Hua

AU - Cheng, Chuan Tao

AU - Yang, Wen Bin

AU - Malhotra, Anshoo

AU - Zhou, Qi

PY - 2018/11/1

Y1 - 2018/11/1

N2 - RNA interference is a highly specific as well as efficient technology for gene therapy application in molecular oncology. The present study was planned to develop an efficient and stable tumor selective delivery mechanism for siRNA gene therapy for the purpose of both diagnosis as well as therapy. We have used 20 Male wistar rats for the formation of colon cancer model and utilized albumin as carrier molecule for the delivery of siRNA against vascular endothelial growth factor receptor 2 (VEGF R2). The study results confirmed efficient delivery of siRNA at tumor site as confirmed by tagging of siRNA-albumin complex with 99mTC. Moreover, the expression of VEGF also showed decline after efficient delivery of siRNA at tumor site. The study concluded that albumin is an efficient molecule for the efficient delivery of siRNA at tumor sites.

AB - RNA interference is a highly specific as well as efficient technology for gene therapy application in molecular oncology. The present study was planned to develop an efficient and stable tumor selective delivery mechanism for siRNA gene therapy for the purpose of both diagnosis as well as therapy. We have used 20 Male wistar rats for the formation of colon cancer model and utilized albumin as carrier molecule for the delivery of siRNA against vascular endothelial growth factor receptor 2 (VEGF R2). The study results confirmed efficient delivery of siRNA at tumor site as confirmed by tagging of siRNA-albumin complex with 99mTC. Moreover, the expression of VEGF also showed decline after efficient delivery of siRNA at tumor site. The study concluded that albumin is an efficient molecule for the efficient delivery of siRNA at tumor sites.

KW - Albumin

KW - Colon cancer

KW - Tc

KW - siRNA

UR - https://www.scopus.com/pages/publications/85046342219

U2 - 10.1016/j.cbi.2018.04.028

DO - 10.1016/j.cbi.2018.04.028

M3 - 文章

C2 - 29709588

AN - SCOPUS:85046342219

SN - 0009-2797

VL - 295

SP - 93

EP - 96

JO - Chemico-Biological Interactions

JF - Chemico-Biological Interactions

ER -

Potential of siRNA-albumin complex against cancer

Abstract

Keywords

UN SDGs

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