TY - JOUR
T1 - Polymorphisms in the TERT gene are associated with lung cancer risk in the Chinese Han population
AU - Gao, Lei
AU - Thakur, Asmitananda
AU - Liang, Yiqian
AU - Zhang, Shuo
AU - Wang, Ting
AU - Chen, Tianjun
AU - Meng, Junhui
AU - Wang, Li
AU - Wu, Fang
AU - Jin, Tianbo
AU - Li, Xiaolan
AU - Liu, Johnson J.
AU - Chen, Chao
AU - Chen, Mingwei
N1 - Publisher Copyright:
© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Lung cancer has the highest mortality rate among cancers; however, its nosogenesis is still unclear. Genome-wide association studies have shown that the telomerase reverse transcriptase (TERT) gene, located in the chromosome 5p15.33 region, is one of the genes associated with the risk of lung cancer. In this case'control study, we genotyped 11 tag single-nucleotide polymorphisms of the TERT gene to evaluate their association with lung cancer risk in the Han Chinese population. Two tag single-nucleotide polymorphisms were found to be associated with lung cancer risk on using the ÷2-test: rs4246742 [odds ratio (OR)=0.77, 95% confidence interval (CI) 0.60'0.98; P=0.03] and rs2853672 (OR=1.26, 95% CI 1.01'1.57; P=0.045). By using SNPStats software we also found rs2242652 (OR=1.47, 95% CI 1.02'2.13; P=0.04) in the dominant model and rs2736098 (OR=1.38, 95% CI 1.06'1.80; P=0.017), rs2853672 (OR=1.41, 95% CI 1.11'1.80; P=0.0048), and rs4246742 (OR=0.75, 95% CI 0.58'0.97; P=0.029) in the log-additive model. 'T/C-T/T' of rs10069690 conferred an increased risk for male sex in the dominant model (OR=1.80, 95% CI, 1.05'3.08; P=0.03) and 'TC' increased risk for male sex in the overdominant model (OR=1.85, 95% CI, 1.08'3.17; P=0.031). Our findings, combined with previous studies, suggest that polymorphisms in the TERT gene contribute to the risk for lung cancer in the Chinese Han population.
AB - Lung cancer has the highest mortality rate among cancers; however, its nosogenesis is still unclear. Genome-wide association studies have shown that the telomerase reverse transcriptase (TERT) gene, located in the chromosome 5p15.33 region, is one of the genes associated with the risk of lung cancer. In this case'control study, we genotyped 11 tag single-nucleotide polymorphisms of the TERT gene to evaluate their association with lung cancer risk in the Han Chinese population. Two tag single-nucleotide polymorphisms were found to be associated with lung cancer risk on using the ÷2-test: rs4246742 [odds ratio (OR)=0.77, 95% confidence interval (CI) 0.60'0.98; P=0.03] and rs2853672 (OR=1.26, 95% CI 1.01'1.57; P=0.045). By using SNPStats software we also found rs2242652 (OR=1.47, 95% CI 1.02'2.13; P=0.04) in the dominant model and rs2736098 (OR=1.38, 95% CI 1.06'1.80; P=0.017), rs2853672 (OR=1.41, 95% CI 1.11'1.80; P=0.0048), and rs4246742 (OR=0.75, 95% CI 0.58'0.97; P=0.029) in the log-additive model. 'T/C-T/T' of rs10069690 conferred an increased risk for male sex in the dominant model (OR=1.80, 95% CI, 1.05'3.08; P=0.03) and 'TC' increased risk for male sex in the overdominant model (OR=1.85, 95% CI, 1.08'3.17; P=0.031). Our findings, combined with previous studies, suggest that polymorphisms in the TERT gene contribute to the risk for lung cancer in the Chinese Han population.
KW - Case'control studies
KW - Lung cancer
KW - TERT gene
KW - Tag single-nucleotide polymorphisms
UR - https://www.scopus.com/pages/publications/84914094721
U2 - 10.1097/CEJ.0000000000000086
DO - 10.1097/CEJ.0000000000000086
M3 - 文章
C2 - 25254308
AN - SCOPUS:84914094721
SN - 0959-8278
VL - 23
SP - 497
EP - 501
JO - European Journal of Cancer Prevention
JF - European Journal of Cancer Prevention
IS - 6
ER -
