Polymer Applied in Hydrogel Wound Dressing for Wound Healing: Modification/Functionalization Method and Design Strategies

Hydrogel wound dressings have emerged as a promising solution for wound healing due to their excellent mechanical and biochemical properties. Over recent years, there has been significant progress in expanding the variety of raw materials used for hydrogel formulation along with the development of advanced modification techniques and design approaches that enhance their performance. However, a comprehensive review encompassing diverse polymer modification strategies and design innovations for hydrogel dressings is still lacking in the literature. This review summarizes the use of natural polymers (e.g., chitosan, gelatin, sodium alginate, hyaluronic acid, and dextran) and synthetic polymers (e.g., poly(vinyl alcohol), polyethylene glycol, Pluronic F-127, poly(N-isopropylacrylamide), polyacrylamide, and polypeptides) in hydrogel wound dressings. We further explore the advantages and limitations of these polymers and discuss various modification strategies, including cationic modification, oxidative modification, double-bond modification, catechol modification, etc. The review also addresses design principles and synthesis methods, aligning polymer modifications with specific requirements in wound healing. Finally, we discuss future challenges and opportunities in the development of advanced hydrogel-based wound dressings.