TY - JOUR
T1 - Plasma urotensin II act as a diagnostic biomarker for acute coronary syndromes
AU - Maharjan, Prabindra
AU - Wu, Yue
AU - He, Ming
AU - Zhang, Weiping
AU - Wang, Xinhong
AU - Shakya, Pramod
AU - Xu, Wei
AU - Liang, Xiao
AU - Zhou, Juan
AU - Yuan, Zuyi
PY - 2014/6
Y1 - 2014/6
N2 - Urotensin II (U-II), one of powerful vasoconstrictor peptides, is involved in the pathogenesis of hypertension, diabetes, myocardial infarction and heart failure. However, its role in patients with acute coronary syndromes (ACS) is still unknown. We performed the present study to measure plasma U-II level in patients with ACS and the healthy subjects in the Chinese Han population. Plasma U-II level in patients with unstable angina (UA 313 ± 286 pg/dl) and acute myocardial infarction (AMI 333 ± 269 pg/dl) was higher than in healthy controls (183 ± 154 pg/dl). Plasma U-II level is positively correlated with the Gensini score (r = 0.285, P = 0.003) and Apo B level (r = 0.239, P = 0.015). Moreover, the area under the receiver operating characteristic curve for the combination of CRP and U-II was significantly higher than it for CRP (P = 0.024). We conclude that U-II, which is elevated in ACS patients, may act as a clinical non-invasive biomarker for ACS diagnosis.
AB - Urotensin II (U-II), one of powerful vasoconstrictor peptides, is involved in the pathogenesis of hypertension, diabetes, myocardial infarction and heart failure. However, its role in patients with acute coronary syndromes (ACS) is still unknown. We performed the present study to measure plasma U-II level in patients with ACS and the healthy subjects in the Chinese Han population. Plasma U-II level in patients with unstable angina (UA 313 ± 286 pg/dl) and acute myocardial infarction (AMI 333 ± 269 pg/dl) was higher than in healthy controls (183 ± 154 pg/dl). Plasma U-II level is positively correlated with the Gensini score (r = 0.285, P = 0.003) and Apo B level (r = 0.239, P = 0.015). Moreover, the area under the receiver operating characteristic curve for the combination of CRP and U-II was significantly higher than it for CRP (P = 0.024). We conclude that U-II, which is elevated in ACS patients, may act as a clinical non-invasive biomarker for ACS diagnosis.
KW - Acute coronary syndromes
KW - Atherosclerosis
KW - Unstable angina
KW - Urotensin II
UR - https://www.scopus.com/pages/publications/84899483133
U2 - 10.1007/s10989-013-9376-6
DO - 10.1007/s10989-013-9376-6
M3 - 文章
AN - SCOPUS:84899483133
SN - 1573-3149
VL - 20
SP - 145
EP - 151
JO - International Journal of Peptide Research and Therapeutics
JF - International Journal of Peptide Research and Therapeutics
IS - 2
ER -
