Plasma-Activated Hydrogel Synergies With Paclitaxel to Enhance the Anticancer Efficacy

Zewei Wang; Xixi Jing; Zijin Wu; Shengduo Xu; Tong Wu; Shiyao Wang; Jishen Zhang; Zifeng Wang; Dingxin Liu; Hao Zhang; Mingzhe Rong

doi:10.1002/ppap.202400167

Plasma-Activated Hydrogel Synergies With Paclitaxel to Enhance the Anticancer Efficacy

Zewei Wang
, Xixi Jing
, Zijin Wu
, Shengduo Xu
, Tong Wu
, Shiyao Wang
, Jishen Zhang
, Zifeng Wang
, Dingxin Liu
, Hao Zhang
, Mingzhe Rong

School of Electrical Engineering

Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Cold atmospheric plasma-activated hydrogel (PAH) exhibits excellent loading and slow-release capacity for plasma-generated reactive species. In this study, plasma-activated pluronic F127 hydrogel (PAH_-PF127) was obtained using surface dielectric barrier discharge (SDBD), and the anticancer effects of PAH_-F127 synergies with the clinical drug paclitaxel (PTX) were investigated. The results indicated that PAH_-PF127 could load plasma-generated long-lived reactive species efficiently, and in vitro research revealed that PAH_-PF127 exerts significant anticancer effects by inducing intracellular oxidative stress, and synergies with 50 μg/mL (low-dose) PTX could easily replace 200 μg/mL (high-dose) PTX alone. These results suggested that PAH_-PF127 has the potential to address the toxic side effects of high-dose drugs and expand the application of plasma technology in anticancer treatment.

Original language	English
Article number	2400167
Journal	Plasma Processes and Polymers
Volume	22
Issue number	2
DOIs	https://doi.org/10.1002/ppap.202400167
State	Published - Feb 2025

Keywords

anticancer effect
cold atmospheric plasma
plasma-activated hydrogel
reactive oxygen and nitrogen species

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10.1002/ppap.202400167

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title = "Plasma-Activated Hydrogel Synergies With Paclitaxel to Enhance the Anticancer Efficacy",

abstract = "Cold atmospheric plasma-activated hydrogel (PAH) exhibits excellent loading and slow-release capacity for plasma-generated reactive species. In this study, plasma-activated pluronic F127 hydrogel (PAH-PF127) was obtained using surface dielectric barrier discharge (SDBD), and the anticancer effects of PAH-F127 synergies with the clinical drug paclitaxel (PTX) were investigated. The results indicated that PAH-PF127 could load plasma-generated long-lived reactive species efficiently, and in vitro research revealed that PAH-PF127 exerts significant anticancer effects by inducing intracellular oxidative stress, and synergies with 50 μg/mL (low-dose) PTX could easily replace 200 μg/mL (high-dose) PTX alone. These results suggested that PAH-PF127 has the potential to address the toxic side effects of high-dose drugs and expand the application of plasma technology in anticancer treatment.",

keywords = "anticancer effect, cold atmospheric plasma, plasma-activated hydrogel, reactive oxygen and nitrogen species",

author = "Zewei Wang and Xixi Jing and Zijin Wu and Shengduo Xu and Tong Wu and Shiyao Wang and Jishen Zhang and Zifeng Wang and Dingxin Liu and Hao Zhang and Mingzhe Rong",

note = "Publisher Copyright: {\textcopyright} 2024 Wiley-VCH GmbH.",

year = "2025",

month = feb,

doi = "10.1002/ppap.202400167",

language = "英语",

volume = "22",

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TY - JOUR

T1 - Plasma-Activated Hydrogel Synergies With Paclitaxel to Enhance the Anticancer Efficacy

AU - Wang, Zewei

AU - Jing, Xixi

AU - Wu, Zijin

AU - Xu, Shengduo

AU - Wu, Tong

AU - Wang, Shiyao

AU - Zhang, Jishen

AU - Wang, Zifeng

AU - Liu, Dingxin

AU - Zhang, Hao

AU - Rong, Mingzhe

PY - 2025/2

Y1 - 2025/2

N2 - Cold atmospheric plasma-activated hydrogel (PAH) exhibits excellent loading and slow-release capacity for plasma-generated reactive species. In this study, plasma-activated pluronic F127 hydrogel (PAH-PF127) was obtained using surface dielectric barrier discharge (SDBD), and the anticancer effects of PAH-F127 synergies with the clinical drug paclitaxel (PTX) were investigated. The results indicated that PAH-PF127 could load plasma-generated long-lived reactive species efficiently, and in vitro research revealed that PAH-PF127 exerts significant anticancer effects by inducing intracellular oxidative stress, and synergies with 50 μg/mL (low-dose) PTX could easily replace 200 μg/mL (high-dose) PTX alone. These results suggested that PAH-PF127 has the potential to address the toxic side effects of high-dose drugs and expand the application of plasma technology in anticancer treatment.

AB - Cold atmospheric plasma-activated hydrogel (PAH) exhibits excellent loading and slow-release capacity for plasma-generated reactive species. In this study, plasma-activated pluronic F127 hydrogel (PAH-PF127) was obtained using surface dielectric barrier discharge (SDBD), and the anticancer effects of PAH-F127 synergies with the clinical drug paclitaxel (PTX) were investigated. The results indicated that PAH-PF127 could load plasma-generated long-lived reactive species efficiently, and in vitro research revealed that PAH-PF127 exerts significant anticancer effects by inducing intracellular oxidative stress, and synergies with 50 μg/mL (low-dose) PTX could easily replace 200 μg/mL (high-dose) PTX alone. These results suggested that PAH-PF127 has the potential to address the toxic side effects of high-dose drugs and expand the application of plasma technology in anticancer treatment.

KW - anticancer effect

KW - cold atmospheric plasma

KW - plasma-activated hydrogel

KW - reactive oxygen and nitrogen species

UR - https://www.scopus.com/pages/publications/85208548602

U2 - 10.1002/ppap.202400167

DO - 10.1002/ppap.202400167

M3 - 文章

AN - SCOPUS:85208548602

SN - 1612-8850

VL - 22

JO - Plasma Processes and Polymers

JF - Plasma Processes and Polymers

IS - 2

M1 - 2400167

ER -

Plasma-Activated Hydrogel Synergies With Paclitaxel to Enhance the Anticancer Efficacy

Abstract

Keywords

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