PKM2 promotes stemness of breast cancer cell by through Wnt/β-catenin pathway

Zheng Zhao; Zhangjun Song; Zijun Liao; Zhigang Liu; Haifeng Sun; Baoxia Lei; Wenjuan Chen; Chengxue Dang

doi:10.1007/s13277-015-4121-8

PKM2 promotes stemness of breast cancer cell by through Wnt/β-catenin pathway

Zheng Zhao
, Zhangjun Song
, Zijun Liao
, Zhigang Liu
, Haifeng Sun
, Baoxia Lei
, Wenjuan Chen
, Chengxue Dang

Health Science Center

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Metastasis is one of the main causes of breast cancer (BCa)-related deaths in female. It has been reported that cancer stem cell played an important role in metastasis. Here we first revealed a specific role of pyruvate kinase isozymes M2 (PKM2) in the stemness of breast cancer cells. Breast cancer tissue analysis confirmed the upregulation of PKM2 in breast cancer, and high PKM2 levels were associated with poor prognosis of breast cancer patients. Holoclone assay and colony formation assay significantly elucidated the role of PKM2 in the self-renewal of breast cancer cells. Moreover, PKM2 elevated the proportion of stem cell and the ability of sphere formation in breast cancer cells. PKM2 played its functional role in stemness by regulating β-catenin. Collectively, we identified critical roles of PKM2 in the stemness of breast cancer cells which may elevate the therapeutic effect on breast cancer patients.

Original language	English
Pages (from-to)	4223-4234
Number of pages	12
Journal	Tumor Biology
Volume	37
Issue number	3
DOIs	https://doi.org/10.1007/s13277-015-4121-8
State	Published - 1 Mar 2016

Keywords

Cancer stem cell
Holoclone
Pyruvate kinase isozymes M2
Stemness
β-Catenin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13277-015-4121-8

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@article{18be4260b07d4215b9f937c1002ee5e0,

title = "PKM2 promotes stemness of breast cancer cell by through Wnt/β-catenin pathway",

abstract = "Metastasis is one of the main causes of breast cancer (BCa)-related deaths in female. It has been reported that cancer stem cell played an important role in metastasis. Here we first revealed a specific role of pyruvate kinase isozymes M2 (PKM2) in the stemness of breast cancer cells. Breast cancer tissue analysis confirmed the upregulation of PKM2 in breast cancer, and high PKM2 levels were associated with poor prognosis of breast cancer patients. Holoclone assay and colony formation assay significantly elucidated the role of PKM2 in the self-renewal of breast cancer cells. Moreover, PKM2 elevated the proportion of stem cell and the ability of sphere formation in breast cancer cells. PKM2 played its functional role in stemness by regulating β-catenin. Collectively, we identified critical roles of PKM2 in the stemness of breast cancer cells which may elevate the therapeutic effect on breast cancer patients.",

keywords = "Cancer stem cell, Holoclone, Pyruvate kinase isozymes M2, Stemness, β-Catenin",

author = "Zheng Zhao and Zhangjun Song and Zijun Liao and Zhigang Liu and Haifeng Sun and Baoxia Lei and Wenjuan Chen and Chengxue Dang",

note = "Publisher Copyright: {\textcopyright} 2015, International Society of Oncology and BioMarkers (ISOBM).",

year = "2016",

month = mar,

day = "1",

doi = "10.1007/s13277-015-4121-8",

language = "英语",

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T1 - PKM2 promotes stemness of breast cancer cell by through Wnt/β-catenin pathway

AU - Zhao, Zheng

AU - Song, Zhangjun

AU - Liao, Zijun

AU - Liu, Zhigang

AU - Sun, Haifeng

AU - Lei, Baoxia

AU - Chen, Wenjuan

AU - Dang, Chengxue

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Metastasis is one of the main causes of breast cancer (BCa)-related deaths in female. It has been reported that cancer stem cell played an important role in metastasis. Here we first revealed a specific role of pyruvate kinase isozymes M2 (PKM2) in the stemness of breast cancer cells. Breast cancer tissue analysis confirmed the upregulation of PKM2 in breast cancer, and high PKM2 levels were associated with poor prognosis of breast cancer patients. Holoclone assay and colony formation assay significantly elucidated the role of PKM2 in the self-renewal of breast cancer cells. Moreover, PKM2 elevated the proportion of stem cell and the ability of sphere formation in breast cancer cells. PKM2 played its functional role in stemness by regulating β-catenin. Collectively, we identified critical roles of PKM2 in the stemness of breast cancer cells which may elevate the therapeutic effect on breast cancer patients.

AB - Metastasis is one of the main causes of breast cancer (BCa)-related deaths in female. It has been reported that cancer stem cell played an important role in metastasis. Here we first revealed a specific role of pyruvate kinase isozymes M2 (PKM2) in the stemness of breast cancer cells. Breast cancer tissue analysis confirmed the upregulation of PKM2 in breast cancer, and high PKM2 levels were associated with poor prognosis of breast cancer patients. Holoclone assay and colony formation assay significantly elucidated the role of PKM2 in the self-renewal of breast cancer cells. Moreover, PKM2 elevated the proportion of stem cell and the ability of sphere formation in breast cancer cells. PKM2 played its functional role in stemness by regulating β-catenin. Collectively, we identified critical roles of PKM2 in the stemness of breast cancer cells which may elevate the therapeutic effect on breast cancer patients.

KW - Cancer stem cell

KW - Holoclone

KW - Pyruvate kinase isozymes M2

KW - Stemness

KW - β-Catenin

UR - https://www.scopus.com/pages/publications/84944916516

U2 - 10.1007/s13277-015-4121-8

DO - 10.1007/s13277-015-4121-8

M3 - 文章

C2 - 26493994

AN - SCOPUS:84944916516

SN - 1010-4283

VL - 37

SP - 4223

EP - 4234

JO - Tumor Biology

JF - Tumor Biology

IS - 3

ER -

PKM2 promotes stemness of breast cancer cell by through Wnt/β-catenin pathway

Abstract

Keywords

UN SDGs

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