Abstract
In recent years, the proportion of innovative biomedical in the biotechnology industry has been increasing gradually, which is mainly due to the improvement of upstream technology such as target screening and molecule construction and brings tremendous economic benefit. With the increasing applications of cell culture technology in biomedical industry, demand for its innovation has been increasing. And so it is with the equipment bioreactors. This review introduced the categories, development trend and driving force of bioreactors in biomedical industry. The achievements of novel bioreactors including the applications of novel bioreactor technology and process analytical technology are also summarized. Finally, we discussed the development status and problems of bioreactor industry in China and pointed out that increasing the product quality rather than production is the goal of bioreactor development. This review also expounded the key role of modern bioreactor technology and the "Quality by Design" principles of as well as the developmenet status and trend of bioreactor technology.
| Original language | English |
|---|---|
| Pages (from-to) | 971-980 |
| Number of pages | 10 |
| Journal | Huagong Jinzhan/Chemical Industry and Engineering Progress |
| Volume | 35 |
| Issue number | 4 |
| DOIs | |
| State | Published - 5 Apr 2016 |
| Externally published | Yes |
Keywords
- Biological engineering
- Biological process engineering
- Bioreactor
- Innovative bio-pharmaceutical
- Microreactor
- PAT
- Quality by design