Photoredox-catalyzed selective deuterodefluorination of α,α-difluoroarylacetic esters and amides

Zi Hang Yuan; Hong Xin; Yuan Gao; Guo Wei Sun; Rui Ying Zhao; Xin Hua Duan; Li Na Guo

doi:10.1039/d4qo00781f

Photoredox-catalyzed selective deuterodefluorination of α,α-difluoroarylacetic esters and amides

Zi Hang Yuan
, Hong Xin
, Yuan Gao
, Guo Wei Sun
, Rui Ying Zhao
, Xin Hua Duan
, Li Na Guo

School of Chemistry

Xi'an Jiaotong University
Lanzhou University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A highly selective photocatalytic deuterodefluorination of fluorinated esters with D₂O is presented. By tailoring the catalytic system, a variety of α,α-difluoroaryl acetates underwent selective defluorination/deuteration to afford the 2-fluoro-2-arylacetate-d and 2-arylacetate-d₂ in good yields with excellent deuteration rate.

Original language	English
Pages (from-to)	4479-4486
Number of pages	8
Journal	Organic Chemistry Frontiers
Volume	11
Issue number	16
DOIs	https://doi.org/10.1039/d4qo00781f
State	Published - 22 Jun 2024

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title = "Photoredox-catalyzed selective deuterodefluorination of α,α-difluoroarylacetic esters and amides",

abstract = "A highly selective photocatalytic deuterodefluorination of fluorinated esters with D2O is presented. By tailoring the catalytic system, a variety of α,α-difluoroaryl acetates underwent selective defluorination/deuteration to afford the 2-fluoro-2-arylacetate-d and 2-arylacetate-d2 in good yields with excellent deuteration rate.",

author = "Yuan, \{Zi Hang\} and Hong Xin and Yuan Gao and Sun, \{Guo Wei\} and Zhao, \{Rui Ying\} and Duan, \{Xin Hua\} and Guo, \{Li Na\}",

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year = "2024",

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day = "22",

doi = "10.1039/d4qo00781f",

language = "英语",

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pages = "4479--4486",

journal = "Organic Chemistry Frontiers",

issn = "2052-4110",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Photoredox-catalyzed selective deuterodefluorination of α,α-difluoroarylacetic esters and amides

AU - Yuan, Zi Hang

AU - Xin, Hong

AU - Gao, Yuan

AU - Sun, Guo Wei

AU - Zhao, Rui Ying

AU - Duan, Xin Hua

AU - Guo, Li Na

PY - 2024/6/22

Y1 - 2024/6/22

N2 - A highly selective photocatalytic deuterodefluorination of fluorinated esters with D2O is presented. By tailoring the catalytic system, a variety of α,α-difluoroaryl acetates underwent selective defluorination/deuteration to afford the 2-fluoro-2-arylacetate-d and 2-arylacetate-d2 in good yields with excellent deuteration rate.

AB - A highly selective photocatalytic deuterodefluorination of fluorinated esters with D2O is presented. By tailoring the catalytic system, a variety of α,α-difluoroaryl acetates underwent selective defluorination/deuteration to afford the 2-fluoro-2-arylacetate-d and 2-arylacetate-d2 in good yields with excellent deuteration rate.

UR - https://www.scopus.com/pages/publications/85196956148

U2 - 10.1039/d4qo00781f

DO - 10.1039/d4qo00781f

M3 - 文章

AN - SCOPUS:85196956148

SN - 2052-4110

VL - 11

SP - 4479

EP - 4486

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

IS - 16

ER -

Photoredox-catalyzed selective deuterodefluorination of α,α-difluoroarylacetic esters and amides

Abstract

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