Photo-crosslinked fabrication of novel biocompatible and elastomeric star-shaped inositol-based polymer with highly tunable mechanical behavior and degradation

Meihua Xie; Juan Ge; Yumeng Xue; Yuzhang Du; Bo Lei; Peter X. Ma

doi:10.1016/j.jmbbm.2015.07.011

Photo-crosslinked fabrication of novel biocompatible and elastomeric star-shaped inositol-based polymer with highly tunable mechanical behavior and degradation

Meihua Xie
, Juan Ge
, Yumeng Xue
, Yuzhang Du
, Bo Lei
, Peter X. Ma

Frontier Institute of Science and Technology

Xi'an Jiaotong University
South China University of Technology
University of Michigan, Ann Arbor

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Biodegradable and star-shaped polymers with highly tunable structure and properties have attracted much attention in recent years for potential biomedical applications, due to their special structure. Here, inositol-based star-shaped poly-. l-lactide-poly(ethylene glycol) (INO-PLLA-PEG) biomedical polymer implants were for the first time synthesized by a facile photo-crosslinking method. This biomaterials show controlled elastomeric mechanical properties (~18. MPa in tensile strength, ~200. MPa in modulus, ~200% in elongation), biodegradability and osteoblasts biocompatibility. These results make INO-PLLA-PEG implants highly promising for bone tissue regeneration and drug delivery applications.

Original language	English
Pages (from-to)	163-168
Number of pages	6
Journal	Journal of the Mechanical Behavior of Biomedical Materials
Volume	51
DOIs	https://doi.org/10.1016/j.jmbbm.2015.07.011
State	Published - 1 Nov 2015

Keywords

Biocompatibility
Biodegradation
Biomedical materials
Highly tunable mechanical properties
Photo-crosslinking
Star-shaped polymers

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10.1016/j.jmbbm.2015.07.011

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title = "Photo-crosslinked fabrication of novel biocompatible and elastomeric star-shaped inositol-based polymer with highly tunable mechanical behavior and degradation",

abstract = "Biodegradable and star-shaped polymers with highly tunable structure and properties have attracted much attention in recent years for potential biomedical applications, due to their special structure. Here, inositol-based star-shaped poly-. l-lactide-poly(ethylene glycol) (INO-PLLA-PEG) biomedical polymer implants were for the first time synthesized by a facile photo-crosslinking method. This biomaterials show controlled elastomeric mechanical properties (\textasciitilde{}18. MPa in tensile strength, \textasciitilde{}200. MPa in modulus, \textasciitilde{}200\% in elongation), biodegradability and osteoblasts biocompatibility. These results make INO-PLLA-PEG implants highly promising for bone tissue regeneration and drug delivery applications.",

keywords = "Biocompatibility, Biodegradation, Biomedical materials, Highly tunable mechanical properties, Photo-crosslinking, Star-shaped polymers",

author = "Meihua Xie and Juan Ge and Yumeng Xue and Yuzhang Du and Bo Lei and Ma, \{Peter X.\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = nov,

day = "1",

doi = "10.1016/j.jmbbm.2015.07.011",

language = "英语",

volume = "51",

pages = "163--168",

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TY - JOUR

T1 - Photo-crosslinked fabrication of novel biocompatible and elastomeric star-shaped inositol-based polymer with highly tunable mechanical behavior and degradation

AU - Xie, Meihua

AU - Ge, Juan

AU - Xue, Yumeng

AU - Du, Yuzhang

AU - Lei, Bo

AU - Ma, Peter X.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Biodegradable and star-shaped polymers with highly tunable structure and properties have attracted much attention in recent years for potential biomedical applications, due to their special structure. Here, inositol-based star-shaped poly-. l-lactide-poly(ethylene glycol) (INO-PLLA-PEG) biomedical polymer implants were for the first time synthesized by a facile photo-crosslinking method. This biomaterials show controlled elastomeric mechanical properties (~18. MPa in tensile strength, ~200. MPa in modulus, ~200% in elongation), biodegradability and osteoblasts biocompatibility. These results make INO-PLLA-PEG implants highly promising for bone tissue regeneration and drug delivery applications.

AB - Biodegradable and star-shaped polymers with highly tunable structure and properties have attracted much attention in recent years for potential biomedical applications, due to their special structure. Here, inositol-based star-shaped poly-. l-lactide-poly(ethylene glycol) (INO-PLLA-PEG) biomedical polymer implants were for the first time synthesized by a facile photo-crosslinking method. This biomaterials show controlled elastomeric mechanical properties (~18. MPa in tensile strength, ~200. MPa in modulus, ~200% in elongation), biodegradability and osteoblasts biocompatibility. These results make INO-PLLA-PEG implants highly promising for bone tissue regeneration and drug delivery applications.

KW - Biocompatibility

KW - Biodegradation

KW - Biomedical materials

KW - Highly tunable mechanical properties

KW - Photo-crosslinking

KW - Star-shaped polymers

UR - https://www.scopus.com/pages/publications/84939127800

U2 - 10.1016/j.jmbbm.2015.07.011

DO - 10.1016/j.jmbbm.2015.07.011

M3 - 文章

C2 - 26253207

AN - SCOPUS:84939127800

SN - 1751-6161

VL - 51

SP - 163

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JO - Journal of the Mechanical Behavior of Biomedical Materials

JF - Journal of the Mechanical Behavior of Biomedical Materials

ER -

Photo-crosslinked fabrication of novel biocompatible and elastomeric star-shaped inositol-based polymer with highly tunable mechanical behavior and degradation

Abstract

Keywords

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