PhICl2 and wet DMF: An efficient system for regioselective chloroformyloxylation/a-chlorination of alkenes/a,β-unsaturated compounds

Le Liu; Daisy Zhang-Negrerie; Yunfei Du; Kang Zhao

doi:10.1021/ol403321n

PhICl₂ and wet DMF: An efficient system for regioselective chloroformyloxylation/a-chlorination of alkenes/a,β-unsaturated compounds

Le Liu
, Daisy Zhang-Negrerie
, Yunfei Du
, Kang Zhao

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

PhICl₂ in wet DMF was found to form an efficient system for realizing difunctionalization of various alkenes and olefinic derivatives possessing a wide range of functional groups. This novel methodology provides convenient access to either regioselective chloroformyloxylated products or a-chlorinated olefinic products, depending on the type of structure of the original unsaturated starting material. The mechanism of the reaction is proposed and discussed.

Original language	English
Pages (from-to)	436-439
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	2
DOIs	https://doi.org/10.1021/ol403321n
State	Published - 17 Jan 2014
Externally published	Yes

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10.1021/ol403321n

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title = "PhICl2 and wet DMF: An efficient system for regioselective chloroformyloxylation/a-chlorination of alkenes/a,β-unsaturated compounds",

abstract = "PhICl2 in wet DMF was found to form an efficient system for realizing difunctionalization of various alkenes and olefinic derivatives possessing a wide range of functional groups. This novel methodology provides convenient access to either regioselective chloroformyloxylated products or a-chlorinated olefinic products, depending on the type of structure of the original unsaturated starting material. The mechanism of the reaction is proposed and discussed.",

author = "Le Liu and Daisy Zhang-Negrerie and Yunfei Du and Kang Zhao",

year = "2014",

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journal = "Organic Letters",

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T2 - An efficient system for regioselective chloroformyloxylation/a-chlorination of alkenes/a,β-unsaturated compounds

AU - Liu, Le

AU - Zhang-Negrerie, Daisy

AU - Du, Yunfei

AU - Zhao, Kang

PY - 2014/1/17

Y1 - 2014/1/17

N2 - PhICl2 in wet DMF was found to form an efficient system for realizing difunctionalization of various alkenes and olefinic derivatives possessing a wide range of functional groups. This novel methodology provides convenient access to either regioselective chloroformyloxylated products or a-chlorinated olefinic products, depending on the type of structure of the original unsaturated starting material. The mechanism of the reaction is proposed and discussed.

AB - PhICl2 in wet DMF was found to form an efficient system for realizing difunctionalization of various alkenes and olefinic derivatives possessing a wide range of functional groups. This novel methodology provides convenient access to either regioselective chloroformyloxylated products or a-chlorinated olefinic products, depending on the type of structure of the original unsaturated starting material. The mechanism of the reaction is proposed and discussed.

UR - https://www.scopus.com/pages/publications/84896779980

U2 - 10.1021/ol403321n

DO - 10.1021/ol403321n

M3 - 文章

C2 - 24392959

AN - SCOPUS:84896779980

SN - 1523-7060

VL - 16

SP - 436

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JO - Organic Letters

JF - Organic Letters

IS - 2

ER -

PhICl₂ and wet DMF: An efficient system for regioselective chloroformyloxylation/a-chlorination of alkenes/a,β-unsaturated compounds

Abstract

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