Pharmacokinetics of ferric acid in rat after oral administration of Radix Angelica Sinensis, Rhizoma Chuanxiong and their compound preparations

AIM: To study pharmacokinetics of ferric acid(FA) in rat after oral administration of Radix Angelica Sinensis, Rhizoma Chuanxiong and their compound proparations (fushousan). METHOD: Radix Angelica Sinensis, Rhizoma Chuanxiong and fushousan were given to rats by ig, concentrations of FA in plasma were determined using HPLC method and main pharmacokinetic parameters were estimated. RESULT: Peak concentration of FA in rat plasma occurred at 5 min after ig Radix Angelica Sinensis, Rhizoma Chuanxiong and fushousan. Half-lives were 88.5 ± 23.1, 70.9 ± 14.3 and 67.9 ± 22.4 min, respectively. There existed significant(P < 0.01) differences in plasma concentration and AUC of FA among Radix Angelica Sinensis, Rhizoma Chuanxiong and fushousan. The values of normalized AUC ₁₈₀ by dose of FA were 4375.8 ± 1663.7, 9866.5 ± 2689.5 and 2084.1 ± 405.9 ng·min/ml respectively. The values of normalized c _max by dose of FA were 108.7 ± 33.4, 317 ± 181.3 and 39.5 ± 17.9 ng/ml. CONCLUSION: There existed large differences in absorption content of FA in rat after ig Radix Angelica Sinensis, Rhizoma Chuanxiong and fushousan.