Pharmacokinetics of clopidogrel in healthy Chinese volunteers

Jian Jun Zou; Li Ding; Jie Tan; Hong Wei Fan; Guang Ji Wang; Shao Liang Chen

doi:10.1691/ph.2012.1754

Pharmacokinetics of clopidogrel in healthy Chinese volunteers

Jian Jun Zou
, Li Ding
, Jie Tan
, Hong Wei Fan
, Guang Ji Wang
, Shao Liang Chen

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

There are marked ethnic variabilities in the metabolism of clopidogrel. The pharmacokinetic (PK) characteristics of clopidogrel have been studied previously in whites or Korean volunteers, but these PK characteristics may not be fully extrapolated to the Chinese people. Little is known about the PK characteristics of clopidogrel in Chinese population. The aim of this study was to evaluate the pharmacokinetic profiles of clopidogrel in 20 healthy Chinese volunteers after administration of a single dose of clopidogrel 75 mg. The peak plasma concentration (C _max), time to C _max (T _max ), area under the plasma concentration versus time curve from time 0 h to 36 h (AUC _0-36 ), elimination half-life (t _1/2), clearance rate (CL/F) and apparent volume of distribution (Vd) were (1.804 ± 1.706) ng/ml, (0.7 ± 0.3) h, (2.465 ± 1.693) ng•h/ml, (7.3 ± 7.0) h, (53.09 ± 34.65) × 10 ³ L/h and (447.1 ± 440.8) × 10 ³ L, respectively.

Original language	English
Pages (from-to)	792-794
Number of pages	3
Journal	Pharmazie
Volume	67
Issue number	9
DOIs	https://doi.org/10.1691/ph.2012.1754
State	Published - Sep 2012
Externally published	Yes

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@article{b79a8c48a2014ed2a6a181c303dc5289,

title = "Pharmacokinetics of clopidogrel in healthy Chinese volunteers",

abstract = "There are marked ethnic variabilities in the metabolism of clopidogrel. The pharmacokinetic (PK) characteristics of clopidogrel have been studied previously in whites or Korean volunteers, but these PK characteristics may not be fully extrapolated to the Chinese people. Little is known about the PK characteristics of clopidogrel in Chinese population. The aim of this study was to evaluate the pharmacokinetic profiles of clopidogrel in 20 healthy Chinese volunteers after administration of a single dose of clopidogrel 75 mg. The peak plasma concentration (C max), time to C max (T max ), area under the plasma concentration versus time curve from time 0 h to 36 h (AUC 0-36 ), elimination half-life (t 1/2), clearance rate (CL/F) and apparent volume of distribution (Vd) were (1.804 ± 1.706) ng/ml, (0.7 ± 0.3) h, (2.465 ± 1.693) ng•h/ml, (7.3 ± 7.0) h, (53.09 ± 34.65) × 10 3 L/h and (447.1 ± 440.8) × 10 3 L, respectively.",

author = "Zou, \{Jian Jun\} and Li Ding and Jie Tan and Fan, \{Hong Wei\} and Wang, \{Guang Ji\} and Chen, \{Shao Liang\}",

year = "2012",

month = sep,

doi = "10.1691/ph.2012.1754",

language = "英语",

volume = "67",

pages = "792--794",

journal = "Pharmazie",

issn = "0031-7144",

publisher = "Avoxa – Mediengruppe Deutscher Apotheker GmbH",

number = "9",

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TY - JOUR

T1 - Pharmacokinetics of clopidogrel in healthy Chinese volunteers

AU - Zou, Jian Jun

AU - Ding, Li

AU - Tan, Jie

AU - Fan, Hong Wei

AU - Wang, Guang Ji

AU - Chen, Shao Liang

PY - 2012/9

Y1 - 2012/9

N2 - There are marked ethnic variabilities in the metabolism of clopidogrel. The pharmacokinetic (PK) characteristics of clopidogrel have been studied previously in whites or Korean volunteers, but these PK characteristics may not be fully extrapolated to the Chinese people. Little is known about the PK characteristics of clopidogrel in Chinese population. The aim of this study was to evaluate the pharmacokinetic profiles of clopidogrel in 20 healthy Chinese volunteers after administration of a single dose of clopidogrel 75 mg. The peak plasma concentration (C max), time to C max (T max ), area under the plasma concentration versus time curve from time 0 h to 36 h (AUC 0-36 ), elimination half-life (t 1/2), clearance rate (CL/F) and apparent volume of distribution (Vd) were (1.804 ± 1.706) ng/ml, (0.7 ± 0.3) h, (2.465 ± 1.693) ng•h/ml, (7.3 ± 7.0) h, (53.09 ± 34.65) × 10 3 L/h and (447.1 ± 440.8) × 10 3 L, respectively.

AB - There are marked ethnic variabilities in the metabolism of clopidogrel. The pharmacokinetic (PK) characteristics of clopidogrel have been studied previously in whites or Korean volunteers, but these PK characteristics may not be fully extrapolated to the Chinese people. Little is known about the PK characteristics of clopidogrel in Chinese population. The aim of this study was to evaluate the pharmacokinetic profiles of clopidogrel in 20 healthy Chinese volunteers after administration of a single dose of clopidogrel 75 mg. The peak plasma concentration (C max), time to C max (T max ), area under the plasma concentration versus time curve from time 0 h to 36 h (AUC 0-36 ), elimination half-life (t 1/2), clearance rate (CL/F) and apparent volume of distribution (Vd) were (1.804 ± 1.706) ng/ml, (0.7 ± 0.3) h, (2.465 ± 1.693) ng•h/ml, (7.3 ± 7.0) h, (53.09 ± 34.65) × 10 3 L/h and (447.1 ± 440.8) × 10 3 L, respectively.

UR - https://www.scopus.com/pages/publications/84867193847

U2 - 10.1691/ph.2012.1754

DO - 10.1691/ph.2012.1754

M3 - 文章

C2 - 23016453

AN - SCOPUS:84867193847

SN - 0031-7144

VL - 67

SP - 792

EP - 794

JO - Pharmazie

JF - Pharmazie

IS - 9

ER -

Pharmacokinetics of clopidogrel in healthy Chinese volunteers

Abstract

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