pH responsive polyurethane (core) and cellulose acetate phthalate (shell) electrospun fibers for intravaginal drug delivery

Dawei Hua; Zhongche Liu; Fang Wang; Buhong Gao; Fei Chen; Qilu Zhang; Ranhua Xiong; Jingquan Han; Sangram Keshari Samal; Stefaan C. De Smedt; Chaobo Huang

doi:10.1016/j.carbpol.2016.06.066

pH responsive polyurethane (core) and cellulose acetate phthalate (shell) electrospun fibers for intravaginal drug delivery

Dawei Hua
, Zhongche Liu
, Fang Wang
, Buhong Gao
, Fei Chen
, Qilu Zhang
, Ranhua Xiong
, Jingquan Han
, Sangram Keshari Samal
, Stefaan C. De Smedt
, Chaobo Huang

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

In this study we present the use of co-axial electrospinning to produce core-shell composite micro-/nano- fibers of polyurethane (PU) and cellulose acetate phthalate (CAP). The designed fibers possess enhanced mechanical properties with a tensile strength of 13.27 ± 2.32 MPa, which is a clear improvement over the existing CAP fibers that suffer from a poor mechanical strength (0.2 ± 0.03 MPa). The CAP imparts pH responsiveness to the core-shell structure giving the fibers potential for “semen sensitive” (intravaginal) drug delivery.

Original language	English
Pages (from-to)	1240-1244
Number of pages	5
Journal	Carbohydrate Polymers
Volume	151
DOIs	https://doi.org/10.1016/j.carbpol.2016.06.066
State	Published - 20 Oct 2016
Externally published	Yes

Keywords

Cellulose acetate phthalate
Core-shell electrospinning
Intravaginal drug delivery
Polyurethane

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10.1016/j.carbpol.2016.06.066

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title = "pH responsive polyurethane (core) and cellulose acetate phthalate (shell) electrospun fibers for intravaginal drug delivery",

abstract = "In this study we present the use of co-axial electrospinning to produce core-shell composite micro-/nano- fibers of polyurethane (PU) and cellulose acetate phthalate (CAP). The designed fibers possess enhanced mechanical properties with a tensile strength of 13.27 ± 2.32 MPa, which is a clear improvement over the existing CAP fibers that suffer from a poor mechanical strength (0.2 ± 0.03 MPa). The CAP imparts pH responsiveness to the core-shell structure giving the fibers potential for “semen sensitive” (intravaginal) drug delivery.",

keywords = "Cellulose acetate phthalate, Core-shell electrospinning, Intravaginal drug delivery, Polyurethane",

author = "Dawei Hua and Zhongche Liu and Fang Wang and Buhong Gao and Fei Chen and Qilu Zhang and Ranhua Xiong and Jingquan Han and Samal, \{Sangram Keshari\} and \{De Smedt\}, \{Stefaan C.\} and Chaobo Huang",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2016",

month = oct,

day = "20",

doi = "10.1016/j.carbpol.2016.06.066",

language = "英语",

volume = "151",

pages = "1240--1244",

journal = "Carbohydrate Polymers",

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publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - pH responsive polyurethane (core) and cellulose acetate phthalate (shell) electrospun fibers for intravaginal drug delivery

AU - Hua, Dawei

AU - Liu, Zhongche

AU - Wang, Fang

AU - Gao, Buhong

AU - Chen, Fei

AU - Zhang, Qilu

AU - Xiong, Ranhua

AU - Han, Jingquan

AU - Samal, Sangram Keshari

AU - De Smedt, Stefaan C.

AU - Huang, Chaobo

PY - 2016/10/20

Y1 - 2016/10/20

N2 - In this study we present the use of co-axial electrospinning to produce core-shell composite micro-/nano- fibers of polyurethane (PU) and cellulose acetate phthalate (CAP). The designed fibers possess enhanced mechanical properties with a tensile strength of 13.27 ± 2.32 MPa, which is a clear improvement over the existing CAP fibers that suffer from a poor mechanical strength (0.2 ± 0.03 MPa). The CAP imparts pH responsiveness to the core-shell structure giving the fibers potential for “semen sensitive” (intravaginal) drug delivery.

AB - In this study we present the use of co-axial electrospinning to produce core-shell composite micro-/nano- fibers of polyurethane (PU) and cellulose acetate phthalate (CAP). The designed fibers possess enhanced mechanical properties with a tensile strength of 13.27 ± 2.32 MPa, which is a clear improvement over the existing CAP fibers that suffer from a poor mechanical strength (0.2 ± 0.03 MPa). The CAP imparts pH responsiveness to the core-shell structure giving the fibers potential for “semen sensitive” (intravaginal) drug delivery.

KW - Cellulose acetate phthalate

KW - Core-shell electrospinning

KW - Intravaginal drug delivery

KW - Polyurethane

UR - https://www.scopus.com/pages/publications/84978985717

U2 - 10.1016/j.carbpol.2016.06.066

DO - 10.1016/j.carbpol.2016.06.066

M3 - 文章

C2 - 27474676

AN - SCOPUS:84978985717

SN - 0144-8617

VL - 151

SP - 1240

EP - 1244

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

ER -

pH responsive polyurethane (core) and cellulose acetate phthalate (shell) electrospun fibers for intravaginal drug delivery

Abstract

Keywords

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