Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds: Types, screening methods and functions

Haixia Yang; Lei Xiao; Nanping Wang

doi:10.1111/1753-0407.12506

Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds: Types, screening methods and functions

Haixia Yang
, Lei Xiao
, Nanping Wang

Health Science Center

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Peroxisome proliferator-activated receptor α (PPARα) plays a key role in lipid metabolism and glucose homeostasis and a crucial role in the prevention and treatment of metabolic diseases. Natural dietary compounds, including nutrients and phytochemicals, are PPARα ligands or modulators. High-throughput screening assays have been developed to screen for PPARα ligands and modulators in our diet. In the present review, we discuss recent advances in our knowledge of PPARα, including its structure, function, and ligand and modulator screening assays, and summarize the different types of dietary PPARα ligands and modulators.

Original language	English
Pages (from-to)	341-352
Number of pages	12
Journal	Journal of Diabetes
Volume	9
Issue number	4
DOIs	https://doi.org/10.1111/1753-0407.12506
State	Published - 1 Apr 2017

Keywords

diet
ligand
modulator
peroxisome proliferator-activated receptor α
screening methods

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/1753-0407.12506

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title = "Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds: Types, screening methods and functions",

abstract = "Peroxisome proliferator-activated receptor α (PPARα) plays a key role in lipid metabolism and glucose homeostasis and a crucial role in the prevention and treatment of metabolic diseases. Natural dietary compounds, including nutrients and phytochemicals, are PPARα ligands or modulators. High-throughput screening assays have been developed to screen for PPARα ligands and modulators in our diet. In the present review, we discuss recent advances in our knowledge of PPARα, including its structure, function, and ligand and modulator screening assays, and summarize the different types of dietary PPARα ligands and modulators.",

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author = "Haixia Yang and Lei Xiao and Nanping Wang",

note = "Publisher Copyright: {\textcopyright} 2016 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley \& Sons Australia, Ltd",

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doi = "10.1111/1753-0407.12506",

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T1 - Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds

T2 - Types, screening methods and functions

AU - Yang, Haixia

AU - Xiao, Lei

AU - Wang, Nanping

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Peroxisome proliferator-activated receptor α (PPARα) plays a key role in lipid metabolism and glucose homeostasis and a crucial role in the prevention and treatment of metabolic diseases. Natural dietary compounds, including nutrients and phytochemicals, are PPARα ligands or modulators. High-throughput screening assays have been developed to screen for PPARα ligands and modulators in our diet. In the present review, we discuss recent advances in our knowledge of PPARα, including its structure, function, and ligand and modulator screening assays, and summarize the different types of dietary PPARα ligands and modulators.

AB - Peroxisome proliferator-activated receptor α (PPARα) plays a key role in lipid metabolism and glucose homeostasis and a crucial role in the prevention and treatment of metabolic diseases. Natural dietary compounds, including nutrients and phytochemicals, are PPARα ligands or modulators. High-throughput screening assays have been developed to screen for PPARα ligands and modulators in our diet. In the present review, we discuss recent advances in our knowledge of PPARα, including its structure, function, and ligand and modulator screening assays, and summarize the different types of dietary PPARα ligands and modulators.

KW - diet

KW - ligand

KW - modulator

KW - peroxisome proliferator-activated receptor α

KW - screening methods

UR - https://www.scopus.com/pages/publications/85007085708

U2 - 10.1111/1753-0407.12506

DO - 10.1111/1753-0407.12506

M3 - 文献综述

C2 - 27863018

AN - SCOPUS:85007085708

SN - 1753-0393

VL - 9

SP - 341

EP - 352

JO - Journal of Diabetes

JF - Journal of Diabetes

IS - 4

ER -

Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds: Types, screening methods and functions

Abstract

Keywords

UN SDGs

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