Abstract
OBJECTIVE: To investigate the pathologic changes induced by infusion of 1% methyl violet in the parotid gland of the miniature pig (minipig). METHODS: Methyl violet (either 0.6 ml, 1.0 ml, or 4.0 ml) was injected into parotid glands of fifteen minipigs. The parotid glands were harvested for gross and histopathologic study after 1 week, 2 weeks, 1 month, 3 months and 6 months. RESULTS: The pathological changes induced by retrograde injection of methyl violet included necrosis or atrophy of acinar cells and fibrosis of the gland. The ductal system underwent atrophic changes, and thrombotic obliteration of main duct. CONCLUSION: Retrograde infusion of 1% methyl violet results in complete atrophy and fibrosis of the parotid gland in the minipig.
| Original language | English |
|---|---|
| Pages (from-to) | 91-93 |
| Number of pages | 3 |
| Journal | Chinese Journal of Stomatology |
| Volume | 34 |
| Issue number | 2 |
| State | Published - Mar 1999 |