Partly-O-Diamond Solution-Gate Field-Effect Transistor as an Efficient Biosensor of Glucose

Assessment of glucose concentration is vital for diagnosis and treatment of diabetes mellitus. Since the electrochemical advantages of diamond for biosensing, we introduced partly-oxygen-diamond solution-gate field-effect transistor (SGFET) to detect glucose. Partly-O-diamond was obtained from H-diamond by ultraviolet ozone treatment. Then, 1-pyrenebutyric acid-N-hydroxy succinimide ester and glucose oxidase were modified on diamond surface. At last, shifts of transfer characteristics were applied to determine glucose concentration. The as-prepared biosensor exhibited a wide linear response from 10⁻⁵ to 10⁻¹ M with high sensitivity of −53 mV/log₁₀ [glucose concentration]. Furthermore, this biosensor showed good repeatability and stability in multiple detections.