Paper-based point-of-care test with xeno nucleic acid probes

Jie Hu; Kang Xiao; Birui Jin; Xuyang Zheng; Fanpu Ji; Dan Bai

doi:10.1002/bit.27106

Paper-based point-of-care test with xeno nucleic acid probes

Jie Hu
, Kang Xiao
, Birui Jin
, Xuyang Zheng
, Fanpu Ji
, Dan Bai

Agency for Science, Technology and Research, Singapore
Chinese Center for Disease Control and Prevention
Zhejiang University
Xi'an Technological University
Tangdu Hospital, Fourth Military Medical University
The Second Affiliated Hospital of Xi'an Jiaotong University
Northwestern Polytechnical University Xian

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Bridging the unmet need of efficient point-of-care testing (POCT) in biomedical engineering research and practice with the emerging development in artificial synthetic xeno nucleic acids (XNAs), this review summarized the recent development in paper-based POCT using XNAs as sensing probes. Alongside the signal transducing mode and immobilization methods of XNA probes, a detailed evaluation of probe performance was disclosed. With these new aspects, both researchers in synthetic chemistry / biomedical engineering and physicians in clinical practice could gain new insights in designing, manufacturing and choosing suitable reagents and techniques for POCT.

Original language	English
Pages (from-to)	2764-2777
Number of pages	14
Journal	Biotechnology and Bioengineering
Volume	116
Issue number	10
DOIs	https://doi.org/10.1002/bit.27106
State	Published - 1 Oct 2019
Externally published	Yes

Keywords

aptamer
chemical modification
paper-based analytical devices (PADs)
point-of-care testing (POCT)
xeno nucleic acids (XNAs)

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10.1002/bit.27106

Cite this

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title = "Paper-based point-of-care test with xeno nucleic acid probes",

abstract = "Bridging the unmet need of efficient point-of-care testing (POCT) in biomedical engineering research and practice with the emerging development in artificial synthetic xeno nucleic acids (XNAs), this review summarized the recent development in paper-based POCT using XNAs as sensing probes. Alongside the signal transducing mode and immobilization methods of XNA probes, a detailed evaluation of probe performance was disclosed. With these new aspects, both researchers in synthetic chemistry / biomedical engineering and physicians in clinical practice could gain new insights in designing, manufacturing and choosing suitable reagents and techniques for POCT.",

keywords = "aptamer, chemical modification, paper-based analytical devices (PADs), point-of-care testing (POCT), xeno nucleic acids (XNAs)",

author = "Jie Hu and Kang Xiao and Birui Jin and Xuyang Zheng and Fanpu Ji and Dan Bai",

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AU - Hu, Jie

AU - Xiao, Kang

AU - Jin, Birui

AU - Zheng, Xuyang

AU - Ji, Fanpu

AU - Bai, Dan

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Bridging the unmet need of efficient point-of-care testing (POCT) in biomedical engineering research and practice with the emerging development in artificial synthetic xeno nucleic acids (XNAs), this review summarized the recent development in paper-based POCT using XNAs as sensing probes. Alongside the signal transducing mode and immobilization methods of XNA probes, a detailed evaluation of probe performance was disclosed. With these new aspects, both researchers in synthetic chemistry / biomedical engineering and physicians in clinical practice could gain new insights in designing, manufacturing and choosing suitable reagents and techniques for POCT.

AB - Bridging the unmet need of efficient point-of-care testing (POCT) in biomedical engineering research and practice with the emerging development in artificial synthetic xeno nucleic acids (XNAs), this review summarized the recent development in paper-based POCT using XNAs as sensing probes. Alongside the signal transducing mode and immobilization methods of XNA probes, a detailed evaluation of probe performance was disclosed. With these new aspects, both researchers in synthetic chemistry / biomedical engineering and physicians in clinical practice could gain new insights in designing, manufacturing and choosing suitable reagents and techniques for POCT.

KW - aptamer

KW - chemical modification

KW - paper-based analytical devices (PADs)

KW - point-of-care testing (POCT)

KW - xeno nucleic acids (XNAs)

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EP - 2777

JO - Biotechnology and Bioengineering

JF - Biotechnology and Bioengineering

IS - 10

ER -

Paper-based point-of-care test with xeno nucleic acid probes

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Keywords

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