Pan-cancer analysis shapes the understanding of cancer biology and medicine

Xiaoping Cen; Yuanyuan Lan; Jiansheng Zou; Ruilin Chen; Can Hu; Yahan Tong; Chen Zhang; Jingyue Chen; Yuanmei Wang; Run Zhou; Weiwei He; Tianyu Lu; Fred Dubee; Dragomirka Jovic; Wei Dong; Qingqing Gao; Man Ma; Youyong Lu; Yu Xue; Xiangdong Cheng; Yixue Li; Huanming Yang

doi:10.1002/cac2.70008

Pan-cancer analysis shapes the understanding of cancer biology and medicine

Xiaoping Cen
, Yuanyuan Lan
, Jiansheng Zou
, Ruilin Chen
, Can Hu
, Yahan Tong
, Chen Zhang
, Jingyue Chen
, Yuanmei Wang
, Run Zhou
, Weiwei He
, Tianyu Lu
, Fred Dubee
, Dragomirka Jovic
, Wei Dong
, Qingqing Gao
, Man Ma
, Youyong Lu
, Yu Xue
, Xiangdong Cheng

Yixue Li, Huanming Yang

University of Chinese Academy of Sciences
Chinese Academy of Sciences
BGI Research
Guangzhou Laboratory
Zhejiang University of Technology
BGI Research
Peking University
Huazhong University of Science and Technology
Guangzhou Medical College
BGI-Shenzhen
Zhejiang University

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Advances in multi-omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan-cancer perspective. Pan-cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies. However, continued innovation is required to refine these approaches and deepen our understanding of cancer biology and medicine. This review summarized key findings from pan-cancer research and explored their potential to drive future advancements in oncology.

Original language	English
Pages (from-to)	728-746
Number of pages	19
Journal	Cancer Communications
Volume	45
Issue number	7
DOIs	https://doi.org/10.1002/cac2.70008
State	Published - Jul 2025
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

artificial intelligence
cancer biology
cancer treatment
multi-omics
pan-cancer

Access to Document

10.1002/cac2.70008

Cite this

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title = "Pan-cancer analysis shapes the understanding of cancer biology and medicine",

abstract = "Advances in multi-omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan-cancer perspective. Pan-cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies. However, continued innovation is required to refine these approaches and deepen our understanding of cancer biology and medicine. This review summarized key findings from pan-cancer research and explored their potential to drive future advancements in oncology.",

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author = "Xiaoping Cen and Yuanyuan Lan and Jiansheng Zou and Ruilin Chen and Can Hu and Yahan Tong and Chen Zhang and Jingyue Chen and Yuanmei Wang and Run Zhou and Weiwei He and Tianyu Lu and Fred Dubee and Dragomirka Jovic and Wei Dong and Qingqing Gao and Man Ma and Youyong Lu and Yu Xue and Xiangdong Cheng and Yixue Li and Huanming Yang",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Cancer Communications published by John Wiley \& Sons Australia, Ltd. on behalf of Sun Yat-sen University Cancer Center.",

year = "2025",

month = jul,

doi = "10.1002/cac2.70008",

language = "英语",

volume = "45",

pages = "728--746",

journal = "Cancer Communications",

issn = "2523-3548",

publisher = "John Wiley \& Sons Inc.",

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}

TY - JOUR

T1 - Pan-cancer analysis shapes the understanding of cancer biology and medicine

AU - Cen, Xiaoping

AU - Lan, Yuanyuan

AU - Zou, Jiansheng

AU - Chen, Ruilin

AU - Hu, Can

AU - Tong, Yahan

AU - Zhang, Chen

AU - Chen, Jingyue

AU - Wang, Yuanmei

AU - Zhou, Run

AU - He, Weiwei

AU - Lu, Tianyu

AU - Dubee, Fred

AU - Jovic, Dragomirka

AU - Dong, Wei

AU - Gao, Qingqing

AU - Ma, Man

AU - Lu, Youyong

AU - Xue, Yu

AU - Cheng, Xiangdong

AU - Li, Yixue

AU - Yang, Huanming

PY - 2025/7

Y1 - 2025/7

N2 - Advances in multi-omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan-cancer perspective. Pan-cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies. However, continued innovation is required to refine these approaches and deepen our understanding of cancer biology and medicine. This review summarized key findings from pan-cancer research and explored their potential to drive future advancements in oncology.

AB - Advances in multi-omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan-cancer perspective. Pan-cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies. However, continued innovation is required to refine these approaches and deepen our understanding of cancer biology and medicine. This review summarized key findings from pan-cancer research and explored their potential to drive future advancements in oncology.

KW - artificial intelligence

KW - cancer biology

KW - cancer treatment

KW - multi-omics

KW - pan-cancer

UR - https://www.scopus.com/pages/publications/105000712929

U2 - 10.1002/cac2.70008

DO - 10.1002/cac2.70008

M3 - 文献综述

C2 - 40120098

AN - SCOPUS:105000712929

SN - 2523-3548

VL - 45

SP - 728

EP - 746

JO - Cancer Communications

JF - Cancer Communications

IS - 7

ER -

Pan-cancer analysis shapes the understanding of cancer biology and medicine

Abstract

UN SDGs

Keywords

Access to Document

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