Palladium-/copper-catalyzed regioselective amination and chloroamination of indoles

Xue Yuan Liu; Pin Gao; Yong Wen Shen; Yong Min Liang

doi:10.1021/ol201457y

Palladium-/copper-catalyzed regioselective amination and chloroamination of indoles

Xue Yuan Liu
, Pin Gao
, Yong Wen Shen
, Yong Min Liang

Lanzhou University

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

A palladium-/copper-catalyzed intermolecular C-H amination reaction of indoles has been developed. This reaction proceeds in good to excellent yields to produce a variety of 2-amino-substituted indoles and exhibits excellent regioselectivity at room temperature. Furthermore, chloroamination of indoles provides a simple method for the construction of C-N and C-Cl bonds in one step.

Original language	English
Pages (from-to)	4196-4199
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	16
DOIs	https://doi.org/10.1021/ol201457y
State	Published - 19 Aug 2011
Externally published	Yes

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title = "Palladium-/copper-catalyzed regioselective amination and chloroamination of indoles",

abstract = "A palladium-/copper-catalyzed intermolecular C-H amination reaction of indoles has been developed. This reaction proceeds in good to excellent yields to produce a variety of 2-amino-substituted indoles and exhibits excellent regioselectivity at room temperature. Furthermore, chloroamination of indoles provides a simple method for the construction of C-N and C-Cl bonds in one step.",

author = "Liu, \{Xue Yuan\} and Pin Gao and Shen, \{Yong Wen\} and Liang, \{Yong Min\}",

year = "2011",

month = aug,

day = "19",

doi = "10.1021/ol201457y",

language = "英语",

volume = "13",

pages = "4196--4199",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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T1 - Palladium-/copper-catalyzed regioselective amination and chloroamination of indoles

AU - Liu, Xue Yuan

AU - Gao, Pin

AU - Shen, Yong Wen

AU - Liang, Yong Min

PY - 2011/8/19

Y1 - 2011/8/19

N2 - A palladium-/copper-catalyzed intermolecular C-H amination reaction of indoles has been developed. This reaction proceeds in good to excellent yields to produce a variety of 2-amino-substituted indoles and exhibits excellent regioselectivity at room temperature. Furthermore, chloroamination of indoles provides a simple method for the construction of C-N and C-Cl bonds in one step.

AB - A palladium-/copper-catalyzed intermolecular C-H amination reaction of indoles has been developed. This reaction proceeds in good to excellent yields to produce a variety of 2-amino-substituted indoles and exhibits excellent regioselectivity at room temperature. Furthermore, chloroamination of indoles provides a simple method for the construction of C-N and C-Cl bonds in one step.

UR - https://www.scopus.com/pages/publications/80051699705

U2 - 10.1021/ol201457y

DO - 10.1021/ol201457y

M3 - 文章

AN - SCOPUS:80051699705

SN - 1523-7060

VL - 13

SP - 4196

EP - 4199

JO - Organic Letters

JF - Organic Letters

IS - 16

ER -

Palladium-/copper-catalyzed regioselective amination and chloroamination of indoles

Abstract

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