TY - JOUR
T1 - Palladium-Catalyzed Regio- and Enantioselective Synthesis of Allylic Amines Featuring Tetrasubstituted Tertiary Carbons
AU - Cai, Aijie
AU - Guo, Wusheng
AU - Martínez-Rodríguez, Luis
AU - Kleij, Arjan W.
N1 - Publisher Copyright:
© 2016 American Chemical Society.
PY - 2016/11/2
Y1 - 2016/11/2
N2 - The first asymmetric synthesis of α,α-disubstituted allylic N-arylamines based on a palladium-catalyzed allylic amination has been developed. The protocol uses highly modular vinyl cyclic carbonates and unactivated aromatic amine nucleophiles as substrates. The catalytic process features minimal waste production, ample scope in reaction partners, high asymmetric induction up to 97% ee, and operational simplicity.
AB - The first asymmetric synthesis of α,α-disubstituted allylic N-arylamines based on a palladium-catalyzed allylic amination has been developed. The protocol uses highly modular vinyl cyclic carbonates and unactivated aromatic amine nucleophiles as substrates. The catalytic process features minimal waste production, ample scope in reaction partners, high asymmetric induction up to 97% ee, and operational simplicity.
UR - https://www.scopus.com/pages/publications/84994323501
U2 - 10.1021/jacs.6b08841
DO - 10.1021/jacs.6b08841
M3 - 文章
AN - SCOPUS:84994323501
SN - 0002-7863
VL - 138
SP - 14194
EP - 14197
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 43
ER -