Palladium-catalyzed carbo-heterofunctionalization of alkenes for the synthesis of oxindoles and spirooxindoles

Stéphanie Jaegli; Jeremy Dufour; Hai Long Wei; Tiffany Piou; Xin Hua Duan; Jean Pierre Vors; Luc Neuville; Jieping Zhu

doi:10.1021/ol101778c

Palladium-catalyzed carbo-heterofunctionalization of alkenes for the synthesis of oxindoles and spirooxindoles

Stéphanie Jaegli
, Jeremy Dufour
, Hai Long Wei
, Tiffany Piou
, Xin Hua Duan
, Jean Pierre Vors
, Luc Neuville
, Jieping Zhu

School of Chemistry

Research output: Contribution to journal › Article › peer-review

192 Scopus citations

Abstract

A palladium-catalyzed oxidative carbo-heterofunctionalization of aniline derivatives involving concomitant direct C - H functionalization and C - X bond formation was developed. By simply changing the reaction conditions (solvent and catalyst), either 3,3′-disubstituted oxindole or spirooxindole was accessible from the same starting material.

Original language	English
Pages (from-to)	4498-4501
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	20
DOIs	https://doi.org/10.1021/ol101778c
State	Published - 15 Oct 2010

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10.1021/ol101778c

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title = "Palladium-catalyzed carbo-heterofunctionalization of alkenes for the synthesis of oxindoles and spirooxindoles",

abstract = "A palladium-catalyzed oxidative carbo-heterofunctionalization of aniline derivatives involving concomitant direct C - H functionalization and C - X bond formation was developed. By simply changing the reaction conditions (solvent and catalyst), either 3,3′-disubstituted oxindole or spirooxindole was accessible from the same starting material.",

author = "St{\'e}phanie Jaegli and Jeremy Dufour and Wei, \{Hai Long\} and Tiffany Piou and Duan, \{Xin Hua\} and Vors, \{Jean Pierre\} and Luc Neuville and Jieping Zhu",

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volume = "12",

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journal = "Organic Letters",

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T1 - Palladium-catalyzed carbo-heterofunctionalization of alkenes for the synthesis of oxindoles and spirooxindoles

AU - Jaegli, Stéphanie

AU - Dufour, Jeremy

AU - Wei, Hai Long

AU - Piou, Tiffany

AU - Duan, Xin Hua

AU - Vors, Jean Pierre

AU - Neuville, Luc

AU - Zhu, Jieping

PY - 2010/10/15

Y1 - 2010/10/15

N2 - A palladium-catalyzed oxidative carbo-heterofunctionalization of aniline derivatives involving concomitant direct C - H functionalization and C - X bond formation was developed. By simply changing the reaction conditions (solvent and catalyst), either 3,3′-disubstituted oxindole or spirooxindole was accessible from the same starting material.

AB - A palladium-catalyzed oxidative carbo-heterofunctionalization of aniline derivatives involving concomitant direct C - H functionalization and C - X bond formation was developed. By simply changing the reaction conditions (solvent and catalyst), either 3,3′-disubstituted oxindole or spirooxindole was accessible from the same starting material.

UR - https://www.scopus.com/pages/publications/77957856689

U2 - 10.1021/ol101778c

DO - 10.1021/ol101778c

M3 - 文章

C2 - 20836499

AN - SCOPUS:77957856689

SN - 1523-7060

VL - 12

SP - 4498

EP - 4501

JO - Organic Letters

JF - Organic Letters

IS - 20

ER -

Palladium-catalyzed carbo-heterofunctionalization of alkenes for the synthesis of oxindoles and spirooxindoles

Abstract

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