Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis

Xiaoyu Wang; Mingzhen Zhang; Shireen R.L. Flores; Regina R. Woloshun; Chunhua Yang; Liangjie Yin; Ping Xiang; Xiaodong Xu; Michael D. Garrick; Sadasivan Vidyasagar; Didier Merlin; James F. Collins

doi:10.1016/j.ymthe.2019.01.003

Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis

Xiaoyu Wang
, Mingzhen Zhang
, Shireen R.L. Flores
, Regina R. Woloshun
, Chunhua Yang
, Liangjie Yin
, Ping Xiang
, Xiaodong Xu
, Michael D. Garrick
, Sadasivan Vidyasagar
, Didier Merlin
, James F. Collins

Health Science Center

University of Florida
Georgia State University
Nanjing University
SUNY Buffalo
Department of Veterans Affairs

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Collins and colleagues developed a novel experimental technique to mitigate excess iron accumulation in hepcidin knockout (KO) mice, which model human hereditary hemochromatosis. The approach involved oral intragastric gavage of lipid nanoparticles derived from edible ginger to deliver small interfering RNAs (siRNAs) targeting the main intestinal iron transporter Dmt1.

Original language	English
Pages (from-to)	493-506
Number of pages	14
Journal	Molecular Therapy
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.ymthe.2019.01.003
State	Published - 6 Mar 2019

Keywords

Dmt1 intestine-specific knockout mice
NTBI
Slc11a2
Ussing chamber
hepcidin
hepcidin knockout mice
serum ferritin

Access to Document

10.1016/j.ymthe.2019.01.003

Cite this

Wang, X., Zhang, M., Flores, S. R. L., Woloshun, R. R., Yang, C., Yin, L., Xiang, P., Xu, X., Garrick, M. D., Vidyasagar, S., Merlin, D., & Collins, J. F. (2019). Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis. Molecular Therapy, 27(3), 493-506. https://doi.org/10.1016/j.ymthe.2019.01.003

@article{9356c53a8fff4904a8c47516a7acd3af,

title = "Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis",

abstract = "Collins and colleagues developed a novel experimental technique to mitigate excess iron accumulation in hepcidin knockout (KO) mice, which model human hereditary hemochromatosis. The approach involved oral intragastric gavage of lipid nanoparticles derived from edible ginger to deliver small interfering RNAs (siRNAs) targeting the main intestinal iron transporter Dmt1.",

keywords = "Dmt1 intestine-specific knockout mice, NTBI, Slc11a2, Ussing chamber, hepcidin, hepcidin knockout mice, serum ferritin",

author = "Xiaoyu Wang and Mingzhen Zhang and Flores, \{Shireen R.L.\} and Woloshun, \{Regina R.\} and Chunhua Yang and Liangjie Yin and Ping Xiang and Xiaodong Xu and Garrick, \{Michael D.\} and Sadasivan Vidyasagar and Didier Merlin and Collins, \{James F.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2019",

month = mar,

day = "6",

doi = "10.1016/j.ymthe.2019.01.003",

language = "英语",

volume = "27",

pages = "493--506",

journal = "Molecular Therapy",

issn = "1525-0016",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis

AU - Wang, Xiaoyu

AU - Zhang, Mingzhen

AU - Flores, Shireen R.L.

AU - Woloshun, Regina R.

AU - Yang, Chunhua

AU - Yin, Liangjie

AU - Xiang, Ping

AU - Xu, Xiaodong

AU - Garrick, Michael D.

AU - Vidyasagar, Sadasivan

AU - Merlin, Didier

AU - Collins, James F.

PY - 2019/3/6

Y1 - 2019/3/6

N2 - Collins and colleagues developed a novel experimental technique to mitigate excess iron accumulation in hepcidin knockout (KO) mice, which model human hereditary hemochromatosis. The approach involved oral intragastric gavage of lipid nanoparticles derived from edible ginger to deliver small interfering RNAs (siRNAs) targeting the main intestinal iron transporter Dmt1.

AB - Collins and colleagues developed a novel experimental technique to mitigate excess iron accumulation in hepcidin knockout (KO) mice, which model human hereditary hemochromatosis. The approach involved oral intragastric gavage of lipid nanoparticles derived from edible ginger to deliver small interfering RNAs (siRNAs) targeting the main intestinal iron transporter Dmt1.

KW - Dmt1 intestine-specific knockout mice

KW - NTBI

KW - Slc11a2

KW - Ussing chamber

KW - hepcidin

KW - hepcidin knockout mice

KW - serum ferritin

UR - https://www.scopus.com/pages/publications/85060860409

U2 - 10.1016/j.ymthe.2019.01.003

DO - 10.1016/j.ymthe.2019.01.003

M3 - 文章

C2 - 30713087

AN - SCOPUS:85060860409

SN - 1525-0016

VL - 27

SP - 493

EP - 506

JO - Molecular Therapy

JF - Molecular Therapy

IS - 3

ER -

Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this