TY - JOUR
T1 - Optimal pig donor selection in islet xenotransplantation
T2 - Current status and future perspectives
AU - Zhu, Hai Tao
AU - Yu, Liang
AU - Lyu, Yi
AU - Wang, Bo
PY - 2014/8
Y1 - 2014/8
N2 - Islet transplantation is an attractive treatment of type 1 diabetes mellitus. Xenotransplantation, using the pig as a donor, offers the possibility of an unlimited supply of islet grafts. Published studies demonstrated that pig islets could function in diabetic primates for a long time (>6 months). However, pig-islet xenotransplantation must overcome the selection of an optimal pig donor to obtain an adequate supply of islets with high-quality, to reduce xeno-antigenicity of islet and prolong xenograft survival, and to translate experimental findings into clinical application. This review discusses the suitable pig donor for islet xenotransplantation in terms of pig age, strain, structure/function of islet, and genetically modified pig.
AB - Islet transplantation is an attractive treatment of type 1 diabetes mellitus. Xenotransplantation, using the pig as a donor, offers the possibility of an unlimited supply of islet grafts. Published studies demonstrated that pig islets could function in diabetic primates for a long time (>6 months). However, pig-islet xenotransplantation must overcome the selection of an optimal pig donor to obtain an adequate supply of islets with high-quality, to reduce xeno-antigenicity of islet and prolong xenograft survival, and to translate experimental findings into clinical application. This review discusses the suitable pig donor for islet xenotransplantation in terms of pig age, strain, structure/function of islet, and genetically modified pig.
KW - Donor
KW - Islet
KW - Pig
KW - Xenotransplantation
UR - https://www.scopus.com/pages/publications/84906344767
U2 - 10.1631/jzus.B1400120
DO - 10.1631/jzus.B1400120
M3 - 文献综述
C2 - 25091986
AN - SCOPUS:84906344767
SN - 1673-1581
VL - 15
SP - 681
EP - 691
JO - Journal of Zhejiang University: Science B
JF - Journal of Zhejiang University: Science B
IS - 8
ER -
