On-site, parallel detection of bio-analytes in water by an integrated capillary flow based opto-microfluidic device

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

An integrated capillary-flow driven opto-microfluidic device for on-site, parallel detection of bio-analytes has been demonstrated in this work. An array of capillary-induced flow microchannels and chambers were arranged on a microfluidic chip made of poly(methyl methacrylate). This poly(methyl methacrylate) chip was further integrated with an array of eight ring-shaped organic photodiodes for measuring chemiluminescence of pathogen immunoassays. Highly sensitive detection of chemiluminescence was ensured by the use of gold nanoparticles, which were attached to the chambers of the microfluidic chip. The developed device demonstrated a detection limit in the range of ∼104 cells/mL for bacteria detection in water. Furthermore, the device revealed feasibility to perform parallel detection of two types of bacteria and two types of viruses quantitatively. The presented concept may offer a promising route to realize truly in-the-field devices for medical and/or environmental measurements.

Original languageEnglish
Title of host publication2015 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2015 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages100-105
Number of pages6
ISBN (Electronic)9781479964765
DOIs
StatePublished - 30 Jun 2015
Externally publishedYes
Event2015 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2015 - Torino, Italy
Duration: 7 May 20159 May 2015

Publication series

Name2015 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2015 - Proceedings

Conference

Conference2015 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2015
Country/TerritoryItaly
CityTorino
Period7/05/159/05/15

Keywords

  • capillary flow
  • gold nanoparticles
  • integrated microfluidics
  • luminescence
  • on-site sensors
  • organic photodetectors
  • thermoplastics

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