On-demand tailored mesoporous silica nanoparticles as a theranostic platform for tumor therapy

Tumor microenvironment-sensitive mesoporous silica nanoparticles (MSNs), as up-and-coming attractive nanoplatform, have captured researchers’ attention and created something of a biomedical transformation over the last few decades. This chapter will elucidate recent developments and accomplishments of MSNs in tumor-related cargo conveyance based on the recent work of our group and other groups. In particular, our group emphasizes the design and development of original organic/inorganic hybrid MSNs with on-demand designed functionalities, including aperture chem-environment, surface modifiable properties, traceable fluorescence message and phase state, and a series of stimuli-dependent delivery modalities to solid tumor. These stimuli-released nanoplatforms are capable of accomplishing active/passive tumor selectivity, multiple payload delivery, targeted payload release, real-time tumor/payload imaging, enhanced circulation in blood, and ceaseless therapy around the solid tumor.