Numerical Simulation of Pale Thrombus Formation in a Y-Bifurcation Vessel With the MPS Method

The pale thrombus due to the vessel injury is composed of aggregated activated platelets. Computational fluid dynamics research is a powerful tool to understand the mechanism of pale thrombus formation, and provide scientific basis for prevention and treatment of the related diseases. The Moving Particle Semi-implicit (MPS) method has great priority for such particle suspension problems due to its Lagrangian nature. A numerical model of the pale thrombus formation based on the MPS method was proposed. A platelet is modeled as a rigid MPS particle, a Red Blood Cell (RBC) is composed of 1 kernel particle and 20 adhesive particles, and the adhesion and aggregation forces between platelets and the injured vessel are simulated by the spring model. The pale thrombus formation problem in 2D 90°Y-bifurcation vessel is simulated by the present model. The result shows that the position and size of the thrombus have a significant impact on the RBC distribution in two branch vessels.