Novel biodegradable pH/thermosensitive hydrogels: Part 1. Preparation and characterization

Kai Dong; Wei Xu; Cui Yu You; Jian Feng Xing; Ye Ji Zhang; Yang Gao; Ke Wang

doi:10.1080/00914037.2013.769233

Novel biodegradable pH/thermosensitive hydrogels: Part 1. Preparation and characterization

Kai Dong
, Wei Xu
, Cui Yu You
, Jian Feng Xing
, Ye Ji Zhang
, Yang Gao
, Ke Wang

Health Science Center

Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A series of biodegradable and pH/thermosensitive hydrogels based on monomethoxyl poly(ethylene glycol) (MPEG), poly(ε-caprolactone) (PCL), methylacrylic acid (MAA), and N-Isopropylacrylamide (NIPAAm) were prepared by UV-initiated free radical polymerization method. Swelling behavior and hydrolytic degradable behavior in aqueous medium with different pH values and pH/thermosensitivity of the hydrogels were studied in detail. The prepared biodegradable pH/thermo-sensitive hydrogels based on PCL, MPEG, MAA, and NIPAAm may have great potential application in smart drug delivery system.

Original language	English
Pages (from-to)	726-732
Number of pages	7
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	62
Issue number	14
DOIs	https://doi.org/10.1080/00914037.2013.769233
State	Published - 28 Jun 2013

Keywords

Biodegradable
degradation
pH/thermosensitive
swelling/deswelling

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10.1080/00914037.2013.769233

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abstract = "A series of biodegradable and pH/thermosensitive hydrogels based on monomethoxyl poly(ethylene glycol) (MPEG), poly(ε-caprolactone) (PCL), methylacrylic acid (MAA), and N-Isopropylacrylamide (NIPAAm) were prepared by UV-initiated free radical polymerization method. Swelling behavior and hydrolytic degradable behavior in aqueous medium with different pH values and pH/thermosensitivity of the hydrogels were studied in detail. The prepared biodegradable pH/thermo-sensitive hydrogels based on PCL, MPEG, MAA, and NIPAAm may have great potential application in smart drug delivery system.",

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author = "Kai Dong and Wei Xu and You, \{Cui Yu\} and Xing, \{Jian Feng\} and Zhang, \{Ye Ji\} and Yang Gao and Ke Wang",

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T1 - Novel biodegradable pH/thermosensitive hydrogels

T2 - Part 1. Preparation and characterization

AU - Dong, Kai

AU - Xu, Wei

AU - You, Cui Yu

AU - Xing, Jian Feng

AU - Zhang, Ye Ji

AU - Gao, Yang

AU - Wang, Ke

PY - 2013/6/28

Y1 - 2013/6/28

N2 - A series of biodegradable and pH/thermosensitive hydrogels based on monomethoxyl poly(ethylene glycol) (MPEG), poly(ε-caprolactone) (PCL), methylacrylic acid (MAA), and N-Isopropylacrylamide (NIPAAm) were prepared by UV-initiated free radical polymerization method. Swelling behavior and hydrolytic degradable behavior in aqueous medium with different pH values and pH/thermosensitivity of the hydrogels were studied in detail. The prepared biodegradable pH/thermo-sensitive hydrogels based on PCL, MPEG, MAA, and NIPAAm may have great potential application in smart drug delivery system.

AB - A series of biodegradable and pH/thermosensitive hydrogels based on monomethoxyl poly(ethylene glycol) (MPEG), poly(ε-caprolactone) (PCL), methylacrylic acid (MAA), and N-Isopropylacrylamide (NIPAAm) were prepared by UV-initiated free radical polymerization method. Swelling behavior and hydrolytic degradable behavior in aqueous medium with different pH values and pH/thermosensitivity of the hydrogels were studied in detail. The prepared biodegradable pH/thermo-sensitive hydrogels based on PCL, MPEG, MAA, and NIPAAm may have great potential application in smart drug delivery system.

KW - Biodegradable

KW - degradation

KW - pH/thermosensitive

KW - swelling/deswelling

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DO - 10.1080/00914037.2013.769233

M3 - 文章

AN - SCOPUS:84879678942

SN - 0091-4037

VL - 62

SP - 726

EP - 732

JO - International Journal of Polymeric Materials and Polymeric Biomaterials

JF - International Journal of Polymeric Materials and Polymeric Biomaterials

IS - 14

ER -

Novel biodegradable pH/thermosensitive hydrogels: Part 1. Preparation and characterization

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Keywords

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