Notice of Removal: FUS cavitation induced injury and localized atherosclerosis plaques of rabbit abdominal arterial endothelium

Early detection and diagnosis of high-risk vulnerable plaques can reduce the death rate attributable to atherosclerosis. Many attempts to identify plaques have focused on in vivo imaging techniques. Animal models with foregone plaque sites will be valuable to evaluate the validity of the imaging methods. However, in traditional balloon injury models, the sites and size of generated plaques are uncertain and uncontrolled. Based on the 'response-to-injury' hypothesis, lesions in the artery's endothelium might be the main mechanism. Therefore, we utilized focused ultrasound(FUS) cavitation to generate localized endothelial lesions instead of balloon, and thereby induced localized, size-controlled plaques combined with high cholesterol diet.