Nickel-Catalyzed Arylboration of Alkenylarenes: Synthesis of Boron-Substituted Quaternary Carbons and Regiodivergent Reactions

Liang An Chen; Alan R. Lear; Pin Gao; M. Kevin Brown

doi:10.1002/anie.201904861

Nickel-Catalyzed Arylboration of Alkenylarenes: Synthesis of Boron-Substituted Quaternary Carbons and Regiodivergent Reactions

Liang An Chen
, Alan R. Lear
, Pin Gao
, M. Kevin Brown

School of Chemistry

Indiana University Bloomington

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

A method for the construction of boron-substituted quaternary carbons or diarylquaternary carbons by arylboration of highly substituted alkenylarenes is presented. A wide range of alkenes and arylbromides can participate in this reaction thus allowing for a diverse assortment of products to be prepared. In addition, a solvent dependent regiodivergent arylboration of 1,2-disubstituted alkenylarenes is presented, thus greatly increasing the scope of products that can be accessed.

Original language	English
Pages (from-to)	10956-10960
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	58
Issue number	32
DOIs	https://doi.org/10.1002/anie.201904861
State	Published - 5 Aug 2019

Keywords

alkenes
arylboration
boron
cross coupling
nickel

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10.1002/anie.201904861

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title = "Nickel-Catalyzed Arylboration of Alkenylarenes: Synthesis of Boron-Substituted Quaternary Carbons and Regiodivergent Reactions",

abstract = "A method for the construction of boron-substituted quaternary carbons or diarylquaternary carbons by arylboration of highly substituted alkenylarenes is presented. A wide range of alkenes and arylbromides can participate in this reaction thus allowing for a diverse assortment of products to be prepared. In addition, a solvent dependent regiodivergent arylboration of 1,2-disubstituted alkenylarenes is presented, thus greatly increasing the scope of products that can be accessed.",

keywords = "alkenes, arylboration, boron, cross coupling, nickel",

author = "Chen, \{Liang An\} and Lear, \{Alan R.\} and Pin Gao and Brown, \{M. Kevin\}",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2019",

month = aug,

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doi = "10.1002/anie.201904861",

language = "英语",

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journal = "Angewandte Chemie - International Edition",

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T1 - Nickel-Catalyzed Arylboration of Alkenylarenes

T2 - Synthesis of Boron-Substituted Quaternary Carbons and Regiodivergent Reactions

AU - Chen, Liang An

AU - Lear, Alan R.

AU - Gao, Pin

AU - Brown, M. Kevin

PY - 2019/8/5

Y1 - 2019/8/5

N2 - A method for the construction of boron-substituted quaternary carbons or diarylquaternary carbons by arylboration of highly substituted alkenylarenes is presented. A wide range of alkenes and arylbromides can participate in this reaction thus allowing for a diverse assortment of products to be prepared. In addition, a solvent dependent regiodivergent arylboration of 1,2-disubstituted alkenylarenes is presented, thus greatly increasing the scope of products that can be accessed.

AB - A method for the construction of boron-substituted quaternary carbons or diarylquaternary carbons by arylboration of highly substituted alkenylarenes is presented. A wide range of alkenes and arylbromides can participate in this reaction thus allowing for a diverse assortment of products to be prepared. In addition, a solvent dependent regiodivergent arylboration of 1,2-disubstituted alkenylarenes is presented, thus greatly increasing the scope of products that can be accessed.

KW - alkenes

KW - arylboration

KW - boron

KW - cross coupling

KW - nickel

UR - https://www.scopus.com/pages/publications/85068350024

U2 - 10.1002/anie.201904861

DO - 10.1002/anie.201904861

M3 - 文章

C2 - 31250959

AN - SCOPUS:85068350024

SN - 1433-7851

VL - 58

SP - 10956

EP - 10960

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 32

ER -

Nickel-Catalyzed Arylboration of Alkenylarenes: Synthesis of Boron-Substituted Quaternary Carbons and Regiodivergent Reactions

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Keywords

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