New photosensitiser 5-ALA-GNPs for photodynamic therapy and its spectral analysis

Cui Ping Yao; Si Jia Wang; Yang Yang; Yu Long Han; Hao Xu; Wei Hui Zeng; Zhen Xi Zhang

doi:10.3964/j.issn.1000-0593(2012)09-2519-04

New photosensitiser 5-ALA-GNPs for photodynamic therapy and its spectral analysis

Cui Ping Yao
, Si Jia Wang
, Yang Yang
, Yu Long Han
, Hao Xu
, Wei Hui Zeng
, Zhen Xi Zhang

Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A novel strategy by means of poly diallyl dimethylammonium chloride (PDDA) was used to make highly mono-dispersed positively charged gold nanoparticles, and 5-ALA was immobilized onto the gold nanoparticles through electrostatic interaction. The conjugation of 5-aminolevulinic acid (5-ALA) and gold nanopartilces were characterized by the integrated tools of resonance Rayleigh scattering (RRS), UV-Vis absorption spectra, transmission electron microscopy (TEM) and laser light scattering. The results demonstrated that 5-ALA can be attached onto positively charged gold nanoparticles. This new photosensitizer is significant for enhancing PDT efficacy clinically.

Original language	English
Pages (from-to)	2519-2522
Number of pages	4
Journal	Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis
Volume	32
Issue number	9
DOIs	https://doi.org/10.3964/j.issn.1000-0593(2012)09-2519-04
State	Published - Sep 2012

Keywords

5-ALA
Gold nanoparticles
Photodynamic therapy

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10.3964/j.issn.1000-0593(2012)09-2519-04

Cite this

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title = "New photosensitiser 5-ALA-GNPs for photodynamic therapy and its spectral analysis",

abstract = "A novel strategy by means of poly diallyl dimethylammonium chloride (PDDA) was used to make highly mono-dispersed positively charged gold nanoparticles, and 5-ALA was immobilized onto the gold nanoparticles through electrostatic interaction. The conjugation of 5-aminolevulinic acid (5-ALA) and gold nanopartilces were characterized by the integrated tools of resonance Rayleigh scattering (RRS), UV-Vis absorption spectra, transmission electron microscopy (TEM) and laser light scattering. The results demonstrated that 5-ALA can be attached onto positively charged gold nanoparticles. This new photosensitizer is significant for enhancing PDT efficacy clinically.",

keywords = "5-ALA, Gold nanoparticles, Photodynamic therapy",

author = "Yao, \{Cui Ping\} and Wang, \{Si Jia\} and Yang Yang and Han, \{Yu Long\} and Hao Xu and Zeng, \{Wei Hui\} and Zhang, \{Zhen Xi\}",

year = "2012",

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doi = "10.3964/j.issn.1000-0593(2012)09-2519-04",

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journal = "Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis",

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TY - JOUR

T1 - New photosensitiser 5-ALA-GNPs for photodynamic therapy and its spectral analysis

AU - Yao, Cui Ping

AU - Wang, Si Jia

AU - Yang, Yang

AU - Han, Yu Long

AU - Xu, Hao

AU - Zeng, Wei Hui

AU - Zhang, Zhen Xi

PY - 2012/9

Y1 - 2012/9

N2 - A novel strategy by means of poly diallyl dimethylammonium chloride (PDDA) was used to make highly mono-dispersed positively charged gold nanoparticles, and 5-ALA was immobilized onto the gold nanoparticles through electrostatic interaction. The conjugation of 5-aminolevulinic acid (5-ALA) and gold nanopartilces were characterized by the integrated tools of resonance Rayleigh scattering (RRS), UV-Vis absorption spectra, transmission electron microscopy (TEM) and laser light scattering. The results demonstrated that 5-ALA can be attached onto positively charged gold nanoparticles. This new photosensitizer is significant for enhancing PDT efficacy clinically.

AB - A novel strategy by means of poly diallyl dimethylammonium chloride (PDDA) was used to make highly mono-dispersed positively charged gold nanoparticles, and 5-ALA was immobilized onto the gold nanoparticles through electrostatic interaction. The conjugation of 5-aminolevulinic acid (5-ALA) and gold nanopartilces were characterized by the integrated tools of resonance Rayleigh scattering (RRS), UV-Vis absorption spectra, transmission electron microscopy (TEM) and laser light scattering. The results demonstrated that 5-ALA can be attached onto positively charged gold nanoparticles. This new photosensitizer is significant for enhancing PDT efficacy clinically.

KW - 5-ALA

KW - Gold nanoparticles

KW - Photodynamic therapy

UR - https://www.scopus.com/pages/publications/84867165923

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DO - 10.3964/j.issn.1000-0593(2012)09-2519-04

M3 - 文章

C2 - 23240430

AN - SCOPUS:84867165923

SN - 1000-0593

VL - 32

SP - 2519

EP - 2522

JO - Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis

JF - Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis

IS - 9

ER -

New photosensitiser 5-ALA-GNPs for photodynamic therapy and its spectral analysis

Abstract

Keywords

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