NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Mario Romani; Vincenzo Sorrentino; Chang Myung Oh; Hao Li; Tanes Imamura de Lima; Hongbo Zhang; Minho Shong; Johan Auwerx

doi:10.1016/j.celrep.2020.108660

NAD⁺ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Mario Romani
, Vincenzo Sorrentino
, Chang Myung Oh
, Hao Li
, Tanes Imamura de Lima
, Hongbo Zhang
, Minho Shong
, Johan Auwerx

School of Life Science and Technology (SLST)

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Romani et al. demonstrate that aging is typified by muscle amyloidosis in a cross-species conserved manner and that late-life treatments aimed at restoring NAD⁺ levels and mitochondrial homeostasis also increase cellular and organismal proteostasis, therefore beneficially impacting on health- and lifespan in a pleiotropic fashion.

Original language	English
Article number	108660
Journal	Cell Reports
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2020.108660
State	Published - 19 Jan 2021

Keywords

aging
amyloid-beta
amyloidosis
inclusion body myositis
mitochondria
NAD
nicotinamide riboside
olaparib
proteostasis
skeletal muscle

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10.1016/j.celrep.2020.108660

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title = "NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle",

abstract = "Romani et al. demonstrate that aging is typified by muscle amyloidosis in a cross-species conserved manner and that late-life treatments aimed at restoring NAD+ levels and mitochondrial homeostasis also increase cellular and organismal proteostasis, therefore beneficially impacting on health- and lifespan in a pleiotropic fashion.",

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author = "Mario Romani and Vincenzo Sorrentino and Oh, \{Chang Myung\} and Hao Li and \{de Lima\}, \{Tanes Imamura\} and Hongbo Zhang and Minho Shong and Johan Auwerx",

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AU - Romani, Mario

AU - Sorrentino, Vincenzo

AU - Oh, Chang Myung

AU - Li, Hao

AU - de Lima, Tanes Imamura

AU - Zhang, Hongbo

AU - Shong, Minho

AU - Auwerx, Johan

PY - 2021/1/19

Y1 - 2021/1/19

N2 - Romani et al. demonstrate that aging is typified by muscle amyloidosis in a cross-species conserved manner and that late-life treatments aimed at restoring NAD+ levels and mitochondrial homeostasis also increase cellular and organismal proteostasis, therefore beneficially impacting on health- and lifespan in a pleiotropic fashion.

AB - Romani et al. demonstrate that aging is typified by muscle amyloidosis in a cross-species conserved manner and that late-life treatments aimed at restoring NAD+ levels and mitochondrial homeostasis also increase cellular and organismal proteostasis, therefore beneficially impacting on health- and lifespan in a pleiotropic fashion.

KW - aging

KW - amyloid-beta

KW - amyloidosis

KW - inclusion body myositis

KW - mitochondria

KW - NAD

KW - nicotinamide riboside

KW - olaparib

KW - proteostasis

KW - skeletal muscle

UR - https://www.scopus.com/pages/publications/85100111327

U2 - 10.1016/j.celrep.2020.108660

DO - 10.1016/j.celrep.2020.108660

M3 - 文章

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AN - SCOPUS:85100111327

SN - 2211-1247

VL - 34

JO - Cell Reports

JF - Cell Reports

IS - 3

M1 - 108660

ER -

NAD⁺ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Abstract

Keywords

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