MPS simulation of primary thrombus formation in capillary

The adhesion, activation and aggregation of platelets play an important role in the primary thrombus formation. In present paper, platelets, plasma, normal and injured endodermis of the vessel are modeled as particles with different characteristics and simulated by the Moving Particle Semi-implicit (MPS) method. In order to simulate the aggregation and adhesion of platelets on the injured endodermis of the vessel, a mechanical adhesion force model is introduced according to the inter-molecular force and physiological interaction between platelets and endodermis is modeled by the stretch and rotation of a spring. By this method, the formation of primary thrombus at the injured endodermis of horizontal and bending vessel is numerically reproduced. Results show that the thrombus forms quickly and the number of adhered platelets will not increase if thrombus has been formed. Through the analysis of flow field, the platelets go through the vibration, steady and potential break free process. Compared with horizontal vessel, the thrombus formation at the bending vessel is slower.