TY - JOUR
T1 - Morphological changes in rabbits died of potassium intoxication
AU - Zhu, Xin ju
AU - Chen, Li ping
AU - Li, Kai
AU - Xu, Yong cheng
AU - Ke, Yong
AU - Wang, Zhen yuan
PY - 2007/2/15
Y1 - 2007/2/15
N2 - OBJECTIVE: Morphologic features of the corpse of rabbits died of potassium intoxication were studied in order to elucidate an objective evidence for forensic determination of death caused by potassium intoxication. METHODS: Macroscopic, microscopic, and ultrastructural (by transmission electron microscopy) changes were observed in the heart, brain, and kidney of rabbits killed by intravenous push or continuous infusion at 100 drips per minute with 0.3% and 1% KCl, respectively. Normal rabbits without any treatment killed by bleeding were used as controls. RESULTS: Macroscopically, cardiac dilatation and congestion/stasis as well as ischemic and hypoxic changes in various organs were observed in rabbits died of potassium injection. Microscopically and ultrastructurally, there were destruction of the cardiac fibers with thickening, concentrating, or disappearing of the Z-line, constriction of the glomerular capillaries, enlargement of the Bowman capsule, thinning and fusion of foot processes, as well as apoptosis with phagocytosis in brain observed, particularly in the group infused with 1% KCl. CONCLUSION: The morphologic changes observed in the heart and kidney appear to be characteristic, supporting death caused by potassium intoxication.
AB - OBJECTIVE: Morphologic features of the corpse of rabbits died of potassium intoxication were studied in order to elucidate an objective evidence for forensic determination of death caused by potassium intoxication. METHODS: Macroscopic, microscopic, and ultrastructural (by transmission electron microscopy) changes were observed in the heart, brain, and kidney of rabbits killed by intravenous push or continuous infusion at 100 drips per minute with 0.3% and 1% KCl, respectively. Normal rabbits without any treatment killed by bleeding were used as controls. RESULTS: Macroscopically, cardiac dilatation and congestion/stasis as well as ischemic and hypoxic changes in various organs were observed in rabbits died of potassium injection. Microscopically and ultrastructurally, there were destruction of the cardiac fibers with thickening, concentrating, or disappearing of the Z-line, constriction of the glomerular capillaries, enlargement of the Bowman capsule, thinning and fusion of foot processes, as well as apoptosis with phagocytosis in brain observed, particularly in the group infused with 1% KCl. CONCLUSION: The morphologic changes observed in the heart and kidney appear to be characteristic, supporting death caused by potassium intoxication.
UR - https://www.scopus.com/pages/publications/75549083048
M3 - 文章
C2 - 17330754
AN - SCOPUS:75549083048
SN - 1004-5619
VL - 23
SP - 23
EP - 25
JO - Journal of Forensic Medicine
JF - Journal of Forensic Medicine
IS - 1
ER -