Molecular Interactions of the Long Noncoding RNA NEAT1 in Cancer

Jingtao Gu; Bo Zhang; Rui An; Weikun Qian; Liang Han; Wanxing Duan; Zheng Wang; Qingyong Ma

doi:10.3390/cancers14164009

Molecular Interactions of the Long Noncoding RNA NEAT1 in Cancer

Jingtao Gu
, Bo Zhang
, Rui An
, Weikun Qian
, Liang Han
, Wanxing Duan
, Zheng Wang
, Qingyong Ma

The First Affiliated Hospital of Xi’an Jiaotong University

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

As one of the best-studied long noncoding RNAs, nuclear paraspeckle assembly transcript 1 (NEAT1) plays a pivotal role in the progression of cancers. NEAT1, especially its isoform NEAT1-1, facilitates the growth and metastasis of various cancers, excluding acute promyelocytic leukemia. NEAT1 can be elevated via transcriptional activation or stability alteration in cancers changing the aggressive phenotype of cancer cells. NEAT1 can also be secreted from other cells and be delivered to cancer cells through exosomes. Hence, elucidating the molecular interaction of NEAT1 may shed light on the future treatment of cancer. Herein, we review the molecular function of NEAT1 in cancer progression, and explain how NEAT1 interacts with RNAs, proteins, and DNA promoter regions to upregulate tumorigenic factors.

Original language	English
Article number	4009
Journal	Cancers
Volume	14
Issue number	16
DOIs	https://doi.org/10.3390/cancers14164009
State	Published - Aug 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

NEAT1
cancer
microRNA
paraspeckle
transcription

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10.3390/cancers14164009

Cite this

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title = "Molecular Interactions of the Long Noncoding RNA NEAT1 in Cancer",

abstract = "As one of the best-studied long noncoding RNAs, nuclear paraspeckle assembly transcript 1 (NEAT1) plays a pivotal role in the progression of cancers. NEAT1, especially its isoform NEAT1-1, facilitates the growth and metastasis of various cancers, excluding acute promyelocytic leukemia. NEAT1 can be elevated via transcriptional activation or stability alteration in cancers changing the aggressive phenotype of cancer cells. NEAT1 can also be secreted from other cells and be delivered to cancer cells through exosomes. Hence, elucidating the molecular interaction of NEAT1 may shed light on the future treatment of cancer. Herein, we review the molecular function of NEAT1 in cancer progression, and explain how NEAT1 interacts with RNAs, proteins, and DNA promoter regions to upregulate tumorigenic factors.",

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author = "Jingtao Gu and Bo Zhang and Rui An and Weikun Qian and Liang Han and Wanxing Duan and Zheng Wang and Qingyong Ma",

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doi = "10.3390/cancers14164009",

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volume = "14",

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T1 - Molecular Interactions of the Long Noncoding RNA NEAT1 in Cancer

AU - Gu, Jingtao

AU - Zhang, Bo

AU - An, Rui

AU - Qian, Weikun

AU - Han, Liang

AU - Duan, Wanxing

AU - Wang, Zheng

AU - Ma, Qingyong

PY - 2022/8

Y1 - 2022/8

N2 - As one of the best-studied long noncoding RNAs, nuclear paraspeckle assembly transcript 1 (NEAT1) plays a pivotal role in the progression of cancers. NEAT1, especially its isoform NEAT1-1, facilitates the growth and metastasis of various cancers, excluding acute promyelocytic leukemia. NEAT1 can be elevated via transcriptional activation or stability alteration in cancers changing the aggressive phenotype of cancer cells. NEAT1 can also be secreted from other cells and be delivered to cancer cells through exosomes. Hence, elucidating the molecular interaction of NEAT1 may shed light on the future treatment of cancer. Herein, we review the molecular function of NEAT1 in cancer progression, and explain how NEAT1 interacts with RNAs, proteins, and DNA promoter regions to upregulate tumorigenic factors.

AB - As one of the best-studied long noncoding RNAs, nuclear paraspeckle assembly transcript 1 (NEAT1) plays a pivotal role in the progression of cancers. NEAT1, especially its isoform NEAT1-1, facilitates the growth and metastasis of various cancers, excluding acute promyelocytic leukemia. NEAT1 can be elevated via transcriptional activation or stability alteration in cancers changing the aggressive phenotype of cancer cells. NEAT1 can also be secreted from other cells and be delivered to cancer cells through exosomes. Hence, elucidating the molecular interaction of NEAT1 may shed light on the future treatment of cancer. Herein, we review the molecular function of NEAT1 in cancer progression, and explain how NEAT1 interacts with RNAs, proteins, and DNA promoter regions to upregulate tumorigenic factors.

KW - NEAT1

KW - cancer

KW - microRNA

KW - paraspeckle

KW - transcription

UR - https://www.scopus.com/pages/publications/85137332187

U2 - 10.3390/cancers14164009

DO - 10.3390/cancers14164009

M3 - 文献综述

AN - SCOPUS:85137332187

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 16

M1 - 4009

ER -

Molecular Interactions of the Long Noncoding RNA NEAT1 in Cancer

Abstract

UN SDGs

Keywords

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