Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine

Li Wang; Shujiang Shang; Xinjiang Kang; Sasa Teng; Feipeng Zhu; Bin Liu; Qihui Wu; Mingli Li; Wei Liu; Huadong Xu; Li Zhou; Ruiying Jiao; Haiqiang Dou; Panli Zuo; Xiaoyu Zhang; Lianghong Zheng; Shirong Wang; Changhe Wang; Zhuan Zhou

doi:10.1038/ncomms4925

Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine

Li Wang
, Shujiang Shang
, Xinjiang Kang
, Sasa Teng
, Feipeng Zhu
, Bin Liu
, Qihui Wu
, Mingli Li
, Wei Liu
, Huadong Xu
, Li Zhou
, Ruiying Jiao
, Haiqiang Dou
, Panli Zuo
, Xiaoyu Zhang
, Lianghong Zheng
, Shirong Wang
, Changhe Wang
, Zhuan Zhou

State Key Lab. of Biomembr. and Membr. Biotechnol. and Beijing Key Lab. of Cardiometabolic Mol. Med., Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University
Peking University

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Striatal dopamine (DA) release can be independently triggered not only by action potentials (APs) in dopaminergic axons but also APs in cholinergic interneurons (ChIs). Nicotine causes addiction by modulating DA release, but with paradoxical findings. Here, we investigate how physiologically relevant levels of nicotine modulate striatal DA release. The optogenetic stimulation of ChIs elicits DA release, which is potently inhibited by nicotine with an IC 50 of 28 ‰nM in the dorsal striatum slice. This ChI-driven DA release is predominantly mediated by ± 6 22* nAChRs. Local electrical stimulus (Estim) activates both dopaminergic axons and ChIs. Nicotine does not affect the AP DA -dependent DA release (AP DA, AP of dopaminergic axon). During burst Estim, nicotine permits the facilitation of DA release by prevention of DA depletion. Our work indicates that cholinergic stimulation-induced DA release is profoundly modulated by physiologically relevant levels of nicotine and resolves the paradoxical observation of nicotine's effects on striatal DA release.

Original language	English
Article number	3925
Journal	Nature Communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms4925
State	Published - 21 May 2014
Externally published	Yes

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title = "Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine",

abstract = "Striatal dopamine (DA) release can be independently triggered not only by action potentials (APs) in dopaminergic axons but also APs in cholinergic interneurons (ChIs). Nicotine causes addiction by modulating DA release, but with paradoxical findings. Here, we investigate how physiologically relevant levels of nicotine modulate striatal DA release. The optogenetic stimulation of ChIs elicits DA release, which is potently inhibited by nicotine with an IC 50 of 28 ‰nM in the dorsal striatum slice. This ChI-driven DA release is predominantly mediated by ± 6 22* nAChRs. Local electrical stimulus (Estim) activates both dopaminergic axons and ChIs. Nicotine does not affect the AP DA -dependent DA release (AP DA, AP of dopaminergic axon). During burst Estim, nicotine permits the facilitation of DA release by prevention of DA depletion. Our work indicates that cholinergic stimulation-induced DA release is profoundly modulated by physiologically relevant levels of nicotine and resolves the paradoxical observation of nicotine's effects on striatal DA release.",

author = "Li Wang and Shujiang Shang and Xinjiang Kang and Sasa Teng and Feipeng Zhu and Bin Liu and Qihui Wu and Mingli Li and Wei Liu and Huadong Xu and Li Zhou and Ruiying Jiao and Haiqiang Dou and Panli Zuo and Xiaoyu Zhang and Lianghong Zheng and Shirong Wang and Changhe Wang and Zhuan Zhou",

year = "2014",

month = may,

day = "21",

doi = "10.1038/ncomms4925",

language = "英语",

volume = "5",

journal = "Nature Communications",

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TY - JOUR

T1 - Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine

AU - Wang, Li

AU - Shang, Shujiang

AU - Kang, Xinjiang

AU - Teng, Sasa

AU - Zhu, Feipeng

AU - Liu, Bin

AU - Wu, Qihui

AU - Li, Mingli

AU - Liu, Wei

AU - Xu, Huadong

AU - Zhou, Li

AU - Jiao, Ruiying

AU - Dou, Haiqiang

AU - Zuo, Panli

AU - Zhang, Xiaoyu

AU - Zheng, Lianghong

AU - Wang, Shirong

AU - Wang, Changhe

AU - Zhou, Zhuan

PY - 2014/5/21

Y1 - 2014/5/21

N2 - Striatal dopamine (DA) release can be independently triggered not only by action potentials (APs) in dopaminergic axons but also APs in cholinergic interneurons (ChIs). Nicotine causes addiction by modulating DA release, but with paradoxical findings. Here, we investigate how physiologically relevant levels of nicotine modulate striatal DA release. The optogenetic stimulation of ChIs elicits DA release, which is potently inhibited by nicotine with an IC 50 of 28 ‰nM in the dorsal striatum slice. This ChI-driven DA release is predominantly mediated by ± 6 22* nAChRs. Local electrical stimulus (Estim) activates both dopaminergic axons and ChIs. Nicotine does not affect the AP DA -dependent DA release (AP DA, AP of dopaminergic axon). During burst Estim, nicotine permits the facilitation of DA release by prevention of DA depletion. Our work indicates that cholinergic stimulation-induced DA release is profoundly modulated by physiologically relevant levels of nicotine and resolves the paradoxical observation of nicotine's effects on striatal DA release.

AB - Striatal dopamine (DA) release can be independently triggered not only by action potentials (APs) in dopaminergic axons but also APs in cholinergic interneurons (ChIs). Nicotine causes addiction by modulating DA release, but with paradoxical findings. Here, we investigate how physiologically relevant levels of nicotine modulate striatal DA release. The optogenetic stimulation of ChIs elicits DA release, which is potently inhibited by nicotine with an IC 50 of 28 ‰nM in the dorsal striatum slice. This ChI-driven DA release is predominantly mediated by ± 6 22* nAChRs. Local electrical stimulus (Estim) activates both dopaminergic axons and ChIs. Nicotine does not affect the AP DA -dependent DA release (AP DA, AP of dopaminergic axon). During burst Estim, nicotine permits the facilitation of DA release by prevention of DA depletion. Our work indicates that cholinergic stimulation-induced DA release is profoundly modulated by physiologically relevant levels of nicotine and resolves the paradoxical observation of nicotine's effects on striatal DA release.

UR - https://www.scopus.com/pages/publications/84901295239

U2 - 10.1038/ncomms4925

DO - 10.1038/ncomms4925

M3 - 文章

C2 - 24968237

AN - SCOPUS:84901295239

SN - 2041-1723

VL - 5

JO - Nature Communications

JF - Nature Communications

M1 - 3925

ER -

Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine

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