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Modeling and reconstruction of micro-structured 3D chitosan/gelatin porous scaffolds using micro-CT

  • Xi'an Jiaotong University

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Three dimensional (3D) channel networks are the key to promise the uniform distribution of nutrients inside 3D hepatic tissue engineering scaffolds and prompt elimination of metabolic products out of the scaffolds. 3D chitosan/gelatin porous scaffolds with predefined internal channels were fabricated and a combination of light microscope, laser confocal microscopy and micro-CT were employed to characterize the structure of porous scaffolds. In order to evaluate the flow field distribution inside the micro-structured 3D scaffolds, a computer reconstructing method based on MicroCT was proposed. According to this evaluating method, a contrast between 3D porous scaffolds with and without predefined internal channels was also performed to assess scaffolds' fluid characters. Results showed that the internal channel of the 3D scaffolds formed the 3D fluid channel network; the uniformity of flow field distribution of the scaffolds fabricated in this paper was better than the simple porous scaffold without micro-fluid channels.

Original languageEnglish
Title of host publicationNumerical Analysis and Applied Mathematics - International Conference on Numerical Analysis and Applied Mathematics 2008
Pages244-248
Number of pages5
DOIs
StatePublished - 2008
EventInternational Conference on Numerical Analysis and Applied Mathematics, ICNAAM 2008 - Psalidi, Kos, Greece
Duration: 16 Sep 200820 Sep 2008

Publication series

NameAIP Conference Proceedings
Volume1048
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

ConferenceInternational Conference on Numerical Analysis and Applied Mathematics, ICNAAM 2008
Country/TerritoryGreece
CityPsalidi, Kos
Period16/09/0820/09/08

Keywords

  • 3D scaffolds
  • Flow field distribution
  • Micro structure reconstruction

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