Abstract
According to the stoichiometric displacement concept and some reasonable assumptions for the surface property and the interaction between the cell membrane stationary phase (CMSP) and drugs, a mixed model of affinity and hydrophobic interaction for drug retention on the CMSP is reported. An equation expressing the "mixed mechanism" was tested by five kinds of calcium antagonists and a rabbit myocardium CMSP with three kinds of different mobile phases. The experimental results basically coincide with that of the theoretical expectation.
| Original language | English |
|---|---|
| Pages (from-to) | 1651-1668 |
| Number of pages | 18 |
| Journal | Journal of Liquid Chromatography and Related Technologies |
| Volume | 28 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2005 |
Keywords
- Calcium antagonist
- Cell membrane chromatography
- Cell membrane stationary phase
- Retention mechanism
- Stoichiometric displacement model
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