TY - JOUR
T1 - MiR-210, a modulator of hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cell
AU - Ding, Lu
AU - Zhao, Le
AU - Chen, Wei
AU - Liu, Ting
AU - Li, Zhen
AU - Li, Xu
N1 - Publisher Copyright:
© 2015, E-Century Publishing Corporation. All rirgts reserved.
PY - 2015/2/28
Y1 - 2015/2/28
N2 - miR-210 has been found consistently induced by hypoxia and implicated in cancer progression. Despite widespread exploration on miR-210 function, little is known about its action on invasion and metastasis of ovarian cancer. In this study, miR-210 was induced by hypoxia in SKOV3 ovarian cancer cells and then suppressed with its specific inhibitor. Repression of miR-210 in hypoxic cells led to upregulation of E-cadherin, downregulation of vimentin and Snail, and attenuation of wound healing capability. On the other hand, miR-210 was overexpressed in normoxic SKOV3 cells, which resulted in decrease of E-cadherin, increase of vimentin and Snail, and facilitation of wound healing capability. These results revealed that miR-210 promoted ovarian cancer cell mobility by acting as a modulator of epithelial-mesenchymal transition (EMT), highlighting the importance of miR-210 in ovarian cancer progression.
AB - miR-210 has been found consistently induced by hypoxia and implicated in cancer progression. Despite widespread exploration on miR-210 function, little is known about its action on invasion and metastasis of ovarian cancer. In this study, miR-210 was induced by hypoxia in SKOV3 ovarian cancer cells and then suppressed with its specific inhibitor. Repression of miR-210 in hypoxic cells led to upregulation of E-cadherin, downregulation of vimentin and Snail, and attenuation of wound healing capability. On the other hand, miR-210 was overexpressed in normoxic SKOV3 cells, which resulted in decrease of E-cadherin, increase of vimentin and Snail, and facilitation of wound healing capability. These results revealed that miR-210 promoted ovarian cancer cell mobility by acting as a modulator of epithelial-mesenchymal transition (EMT), highlighting the importance of miR-210 in ovarian cancer progression.
KW - Epithelial-mesenchymal transition
KW - MiR-210
KW - Ovarian cancer
UR - https://www.scopus.com/pages/publications/84926361218
M3 - 文章
AN - SCOPUS:84926361218
SN - 1940-5901
VL - 8
SP - 2299
EP - 2307
JO - International Journal of Clinical and Experimental Medicine
JF - International Journal of Clinical and Experimental Medicine
IS - 2
ER -
