Mir-17-92 cluster targets phosphatase and tensin homology and ikaros family zinc finger 4 to promote th17-mediated inflammation

Si Qi Liu; Shan Jiang; Chaoran Li; Baojun Zhang; Qi Jing Li

doi:10.1074/jbc.M114.550723

Mir-17-92 cluster targets phosphatase and tensin homology and ikaros family zinc finger 4 to promote th17-mediated inflammation

Si Qi Liu
, Shan Jiang
, Chaoran Li
, Baojun Zhang
, Qi Jing Li

Duke University

Research output: Contribution to journal › Article › peer-review

135 Scopus citations

Abstract

Background: miRNA is a key component of post-transcriptional network governing the fate of T cells. Results: By targeting PTEN and IKZF4, miR-17-92 cluster promotes TH17 differentiation and TH17-related inflammation. Conclusion: miR-19b and miR-17 within the cluster additively promote TH17 responses through distinct regulatory networks. Significance: Our study provides novel regulatory mechanisms and potential therapeutic candidates against autoimmunity.

Original language	English
Pages (from-to)	12446-12456
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	18
DOIs	https://doi.org/10.1074/jbc.M114.550723
State	Published - 2014
Externally published	Yes

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10.1074/jbc.M114.550723

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title = "Mir-17-92 cluster targets phosphatase and tensin homology and ikaros family zinc finger 4 to promote th17-mediated inflammation",

abstract = "Background: miRNA is a key component of post-transcriptional network governing the fate of T cells. Results: By targeting PTEN and IKZF4, miR-17-92 cluster promotes TH17 differentiation and TH17-related inflammation. Conclusion: miR-19b and miR-17 within the cluster additively promote TH17 responses through distinct regulatory networks. Significance: Our study provides novel regulatory mechanisms and potential therapeutic candidates against autoimmunity.",

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year = "2014",

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T1 - Mir-17-92 cluster targets phosphatase and tensin homology and ikaros family zinc finger 4 to promote th17-mediated inflammation

AU - Liu, Si Qi

AU - Jiang, Shan

AU - Li, Chaoran

AU - Zhang, Baojun

AU - Li, Qi Jing

PY - 2014

Y1 - 2014

N2 - Background: miRNA is a key component of post-transcriptional network governing the fate of T cells. Results: By targeting PTEN and IKZF4, miR-17-92 cluster promotes TH17 differentiation and TH17-related inflammation. Conclusion: miR-19b and miR-17 within the cluster additively promote TH17 responses through distinct regulatory networks. Significance: Our study provides novel regulatory mechanisms and potential therapeutic candidates against autoimmunity.

AB - Background: miRNA is a key component of post-transcriptional network governing the fate of T cells. Results: By targeting PTEN and IKZF4, miR-17-92 cluster promotes TH17 differentiation and TH17-related inflammation. Conclusion: miR-19b and miR-17 within the cluster additively promote TH17 responses through distinct regulatory networks. Significance: Our study provides novel regulatory mechanisms and potential therapeutic candidates against autoimmunity.

UR - https://www.scopus.com/pages/publications/84899755840

U2 - 10.1074/jbc.M114.550723

DO - 10.1074/jbc.M114.550723

M3 - 文章

C2 - 24644282

AN - SCOPUS:84899755840

SN - 0021-9258

VL - 289

SP - 12446

EP - 12456

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 18

ER -

Mir-17-92 cluster targets phosphatase and tensin homology and ikaros family zinc finger 4 to promote th17-mediated inflammation

Abstract

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