Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota

Yongfei Hu; Xi Yang; Junjie Qin; Na Lu; Gong Cheng; Na Wu; Yuanlong Pan; Jing Li; Liying Zhu; Xin Wang; Zhiqi Meng; Fangqing Zhao; Di Liu; Juncai Ma; Nan Qin; Chunsheng Xiang; Yonghong Xiao; Lanjuan Li; Huanming Yang; Jian Wang; Ruifu Yang; George F. Gao; Jun Wang; Baoli Zhu

doi:10.1038/ncomms3151

Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota

Yongfei Hu
, Xi Yang
, Junjie Qin
, Na Lu
, Gong Cheng
, Na Wu
, Yuanlong Pan
, Jing Li
, Liying Zhu
, Xin Wang
, Zhiqi Meng
, Fangqing Zhao
, Di Liu
, Juncai Ma
, Nan Qin
, Chunsheng Xiang
, Yonghong Xiao
, Lanjuan Li
, Huanming Yang
, Jian Wang

Ruifu Yang, George F. Gao, Jun Wang, Baoli Zhu

CAS - Institute of Microbiology
BGI-Shenzhen
Zhejiang Academy of Agricultural Sciences
Chinese Academy of Sciences
Zhejiang University
Academy of Military Medical Science China

Research output: Contribution to journal › Article › peer-review

698 Scopus citations

Abstract

The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse the antibiotic resistance genes of gut microbiota from 162 individuals. We identify a total of 1,093 antibiotic resistance genes and find that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals. Single-nucleotide polymorphism-based analysis indicates that antibiotic resistance genes from the two European populations are more closely related while the Chinese ones are clustered separately. We also confirm high abundance of tetracycline resistance genes with this large cohort study. Our study provides a broad view of antibiotic resistance genes in the human gut microbiota.

Original language	English
Article number	2151
Journal	Nature Communications
Volume	4
DOIs	https://doi.org/10.1038/ncomms3151
State	Published - 2013
Externally published	Yes

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10.1038/ncomms3151

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@article{ffe04cb2868842d89272bbe9e6fb3d8f,

title = "Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota",

abstract = "The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse the antibiotic resistance genes of gut microbiota from 162 individuals. We identify a total of 1,093 antibiotic resistance genes and find that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals. Single-nucleotide polymorphism-based analysis indicates that antibiotic resistance genes from the two European populations are more closely related while the Chinese ones are clustered separately. We also confirm high abundance of tetracycline resistance genes with this large cohort study. Our study provides a broad view of antibiotic resistance genes in the human gut microbiota.",

author = "Yongfei Hu and Xi Yang and Junjie Qin and Na Lu and Gong Cheng and Na Wu and Yuanlong Pan and Jing Li and Liying Zhu and Xin Wang and Zhiqi Meng and Fangqing Zhao and Di Liu and Juncai Ma and Nan Qin and Chunsheng Xiang and Yonghong Xiao and Lanjuan Li and Huanming Yang and Jian Wang and Ruifu Yang and Gao, \{George F.\} and Jun Wang and Baoli Zhu",

year = "2013",

doi = "10.1038/ncomms3151",

language = "英语",

volume = "4",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

}

Hu, Y, Yang, X, Qin, J, Lu, N, Cheng, G, Wu, N, Pan, Y, Li, J, Zhu, L, Wang, X, Meng, Z, Zhao, F, Liu, D, Ma, J, Qin, N, Xiang, C, Xiao, Y, Li, L, Yang, H, Wang, J, Yang, R, Gao, GF, Wang, J & Zhu, B 2013, 'Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota', Nature Communications, vol. 4, 2151. https://doi.org/10.1038/ncomms3151

TY - JOUR

T1 - Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota

AU - Hu, Yongfei

AU - Yang, Xi

AU - Qin, Junjie

AU - Lu, Na

AU - Cheng, Gong

AU - Wu, Na

AU - Pan, Yuanlong

AU - Li, Jing

AU - Zhu, Liying

AU - Wang, Xin

AU - Meng, Zhiqi

AU - Zhao, Fangqing

AU - Liu, Di

AU - Ma, Juncai

AU - Qin, Nan

AU - Xiang, Chunsheng

AU - Xiao, Yonghong

AU - Li, Lanjuan

AU - Yang, Huanming

AU - Wang, Jian

AU - Yang, Ruifu

AU - Gao, George F.

AU - Wang, Jun

AU - Zhu, Baoli

PY - 2013

Y1 - 2013

N2 - The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse the antibiotic resistance genes of gut microbiota from 162 individuals. We identify a total of 1,093 antibiotic resistance genes and find that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals. Single-nucleotide polymorphism-based analysis indicates that antibiotic resistance genes from the two European populations are more closely related while the Chinese ones are clustered separately. We also confirm high abundance of tetracycline resistance genes with this large cohort study. Our study provides a broad view of antibiotic resistance genes in the human gut microbiota.

AB - The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse the antibiotic resistance genes of gut microbiota from 162 individuals. We identify a total of 1,093 antibiotic resistance genes and find that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals. Single-nucleotide polymorphism-based analysis indicates that antibiotic resistance genes from the two European populations are more closely related while the Chinese ones are clustered separately. We also confirm high abundance of tetracycline resistance genes with this large cohort study. Our study provides a broad view of antibiotic resistance genes in the human gut microbiota.

UR - https://www.scopus.com/pages/publications/84880831180

U2 - 10.1038/ncomms3151

DO - 10.1038/ncomms3151

M3 - 文章

C2 - 23877117

AN - SCOPUS:84880831180

SN - 2041-1723

VL - 4

JO - Nature Communications

JF - Nature Communications

M1 - 2151

ER -

Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota

Abstract

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