Metabolic interaction of cinildipine with some co-administrated drugs in human liver microsomes

Aim: To study the metabolic interaction of cinildipine with some drugs often co-administrated clinically in human liver microsomes. Method: Chromatographic analysis was performed on Hypersil BDS C₁₈ column. The mobile phase consisted of acetonitril-methanol-water containing 0.01 mol/L tetrabutyl ammonium bromide (55:5:40, v/v/v) and the UV detection wavelength was set at 238 nm. Result: Cyclosporin A, erythromycin and simvastatin could significantly inhibit the metabolism of cinildipine in human liver microsomes, while such drugs as tolbutamide, gliclazide, glimepiride, metformine, captopril and famotidine had no significant inhibitory effect on the metabolism of cinildipine. Conclusion: The inhibitors or substrate of CYP 3A may affect the metabolism of cinildipine.