Mesenchymal stromal cell-based treatment of jaw osteoradionecrosis in swine

Junji Xu; Zongmei Zheng; Dianji Fang; Runtao Gao; Yi Liu; Zhipeng Fan; Chunmei Zhang; Songtao Shi; Songlin Wang

doi:10.3727/096368911X637434

Mesenchymal stromal cell-based treatment of jaw osteoradionecrosis in swine

Junji Xu
, Zongmei Zheng
, Dianji Fang
, Runtao Gao
, Yi Liu
, Zhipeng Fan
, Chunmei Zhang
, Songtao Shi
, Songlin Wang

Health Science Center

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Jaw osteoradionecrosis (ORN) is a common and serious complication of radiation therapy for head and neck cancers. Bone marrow mesenchymal stromal cells (BMMSCs) are multipotent postnatal stem cells and have been widely used in clinical therapies. In the present study, we generated the mandibular ORN model in swine using a combination of single-dose 25-Gy irradiation and tooth extraction. A typical ORN phenotype, including loss of bone regeneration capacity and collagen collapse with the obliteration of vessels, gradually appeared after irradiation. After autologous BMMSC transplantation, new bone and vessels were regenerated, and the advanced mandibular ORN was treated successfully. In summary, we developed a swine model of jaw ORN, and our results indicate that autologous BMMSC transplantation may be a promising therapeutic approach for ORN.

Original language	English
Pages (from-to)	1679-1686
Number of pages	8
Journal	Cell Transplantation
Volume	21
Issue number	8
DOIs	https://doi.org/10.3727/096368911X637434
State	Published - 2012

Keywords

Bone marrow mesenchymal stromal cells (BMMSCs)
Bone regeneration
Jaw osteoradionecrosis (ORN)
Large animal model
Swine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3727/096368911X637434

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title = "Mesenchymal stromal cell-based treatment of jaw osteoradionecrosis in swine",

abstract = "Jaw osteoradionecrosis (ORN) is a common and serious complication of radiation therapy for head and neck cancers. Bone marrow mesenchymal stromal cells (BMMSCs) are multipotent postnatal stem cells and have been widely used in clinical therapies. In the present study, we generated the mandibular ORN model in swine using a combination of single-dose 25-Gy irradiation and tooth extraction. A typical ORN phenotype, including loss of bone regeneration capacity and collagen collapse with the obliteration of vessels, gradually appeared after irradiation. After autologous BMMSC transplantation, new bone and vessels were regenerated, and the advanced mandibular ORN was treated successfully. In summary, we developed a swine model of jaw ORN, and our results indicate that autologous BMMSC transplantation may be a promising therapeutic approach for ORN.",

keywords = "Bone marrow mesenchymal stromal cells (BMMSCs), Bone regeneration, Jaw osteoradionecrosis (ORN), Large animal model, Swine",

author = "Junji Xu and Zongmei Zheng and Dianji Fang and Runtao Gao and Yi Liu and Zhipeng Fan and Chunmei Zhang and Songtao Shi and Songlin Wang",

year = "2012",

doi = "10.3727/096368911X637434",

language = "英语",

volume = "21",

pages = "1679--1686",

journal = "Cell Transplantation",

issn = "0963-6897",

publisher = "SAGE Publications Inc.",

number = "8",

}

TY - JOUR

T1 - Mesenchymal stromal cell-based treatment of jaw osteoradionecrosis in swine

AU - Xu, Junji

AU - Zheng, Zongmei

AU - Fang, Dianji

AU - Gao, Runtao

AU - Liu, Yi

AU - Fan, Zhipeng

AU - Zhang, Chunmei

AU - Shi, Songtao

AU - Wang, Songlin

PY - 2012

Y1 - 2012

N2 - Jaw osteoradionecrosis (ORN) is a common and serious complication of radiation therapy for head and neck cancers. Bone marrow mesenchymal stromal cells (BMMSCs) are multipotent postnatal stem cells and have been widely used in clinical therapies. In the present study, we generated the mandibular ORN model in swine using a combination of single-dose 25-Gy irradiation and tooth extraction. A typical ORN phenotype, including loss of bone regeneration capacity and collagen collapse with the obliteration of vessels, gradually appeared after irradiation. After autologous BMMSC transplantation, new bone and vessels were regenerated, and the advanced mandibular ORN was treated successfully. In summary, we developed a swine model of jaw ORN, and our results indicate that autologous BMMSC transplantation may be a promising therapeutic approach for ORN.

AB - Jaw osteoradionecrosis (ORN) is a common and serious complication of radiation therapy for head and neck cancers. Bone marrow mesenchymal stromal cells (BMMSCs) are multipotent postnatal stem cells and have been widely used in clinical therapies. In the present study, we generated the mandibular ORN model in swine using a combination of single-dose 25-Gy irradiation and tooth extraction. A typical ORN phenotype, including loss of bone regeneration capacity and collagen collapse with the obliteration of vessels, gradually appeared after irradiation. After autologous BMMSC transplantation, new bone and vessels were regenerated, and the advanced mandibular ORN was treated successfully. In summary, we developed a swine model of jaw ORN, and our results indicate that autologous BMMSC transplantation may be a promising therapeutic approach for ORN.

KW - Bone marrow mesenchymal stromal cells (BMMSCs)

KW - Bone regeneration

KW - Jaw osteoradionecrosis (ORN)

KW - Large animal model

KW - Swine

UR - https://www.scopus.com/pages/publications/84864154159

U2 - 10.3727/096368911X637434

DO - 10.3727/096368911X637434

M3 - 文章

C2 - 22469112

AN - SCOPUS:84864154159

SN - 0963-6897

VL - 21

SP - 1679

EP - 1686

JO - Cell Transplantation

JF - Cell Transplantation

IS - 8

ER -

Mesenchymal stromal cell-based treatment of jaw osteoradionecrosis in swine

Abstract

Keywords

UN SDGs

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