Mechanotherapy in oncology: Targeting nuclear mechanics and mechanotransduction

Shaobao Liu; Yuan Li; Yuan Hong; Ming Wang; Hao Zhang; Jinlu Ma; Kai Qu; Guoyou Huang; Tian Jian Lu

doi:10.1016/j.addr.2023.114722

Mechanotherapy in oncology: Targeting nuclear mechanics and mechanotransduction

Shaobao Liu
, Yuan Li
, Yuan Hong
, Ming Wang
, Hao Zhang
, Jinlu Ma
, Kai Qu
, Guoyou Huang
, Tian Jian Lu

Nanjing University of Aeronautics and Astronautics
Xi'an Jiaotong University
Washington University St. Louis
The First Affiliated Hospital of Xi’an Jiaotong University
Wuhan University

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence suggests that characteristic differences are present in the nuclear mechanics and mechanotransduction of cancer cells compared with those of normal cells. Recent advances in understanding nuclear mechanics and mechanotransduction provide not only further insights into the process of malignant transformation but also useful references for developing new therapeutic approaches. Herein, we present an overview of the alterations of nuclear mechanics and mechanotransduction in cancer cells and highlight their implications in cancer mechanotherapy.

Original language	English
Article number	114722
Journal	Advanced Drug Delivery Reviews
Volume	194
DOIs	https://doi.org/10.1016/j.addr.2023.114722
State	Published - Mar 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer cell
Mechanobiology
Mechanotherapy
Mechanotransduction
Nuclear mechanics

Access to Document

10.1016/j.addr.2023.114722

Cite this

@article{5e71ce0d92834f498b94c6de9d36196d,

title = "Mechanotherapy in oncology: Targeting nuclear mechanics and mechanotransduction",

abstract = "Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence suggests that characteristic differences are present in the nuclear mechanics and mechanotransduction of cancer cells compared with those of normal cells. Recent advances in understanding nuclear mechanics and mechanotransduction provide not only further insights into the process of malignant transformation but also useful references for developing new therapeutic approaches. Herein, we present an overview of the alterations of nuclear mechanics and mechanotransduction in cancer cells and highlight their implications in cancer mechanotherapy.",

keywords = "Cancer cell, Mechanobiology, Mechanotherapy, Mechanotransduction, Nuclear mechanics",

author = "Shaobao Liu and Yuan Li and Yuan Hong and Ming Wang and Hao Zhang and Jinlu Ma and Kai Qu and Guoyou Huang and Lu, \{Tian Jian\}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",

year = "2023",

month = mar,

doi = "10.1016/j.addr.2023.114722",

language = "英语",

volume = "194",

journal = "Advanced Drug Delivery Reviews",

issn = "0169-409X",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Mechanotherapy in oncology

T2 - Targeting nuclear mechanics and mechanotransduction

AU - Liu, Shaobao

AU - Li, Yuan

AU - Hong, Yuan

AU - Wang, Ming

AU - Zhang, Hao

AU - Ma, Jinlu

AU - Qu, Kai

AU - Huang, Guoyou

AU - Lu, Tian Jian

PY - 2023/3

Y1 - 2023/3

N2 - Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence suggests that characteristic differences are present in the nuclear mechanics and mechanotransduction of cancer cells compared with those of normal cells. Recent advances in understanding nuclear mechanics and mechanotransduction provide not only further insights into the process of malignant transformation but also useful references for developing new therapeutic approaches. Herein, we present an overview of the alterations of nuclear mechanics and mechanotransduction in cancer cells and highlight their implications in cancer mechanotherapy.

AB - Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence suggests that characteristic differences are present in the nuclear mechanics and mechanotransduction of cancer cells compared with those of normal cells. Recent advances in understanding nuclear mechanics and mechanotransduction provide not only further insights into the process of malignant transformation but also useful references for developing new therapeutic approaches. Herein, we present an overview of the alterations of nuclear mechanics and mechanotransduction in cancer cells and highlight their implications in cancer mechanotherapy.

KW - Cancer cell

KW - Mechanobiology

KW - Mechanotherapy

KW - Mechanotransduction

KW - Nuclear mechanics

UR - https://www.scopus.com/pages/publications/85148011337

U2 - 10.1016/j.addr.2023.114722

DO - 10.1016/j.addr.2023.114722

M3 - 文献综述

C2 - 36738968

AN - SCOPUS:85148011337

SN - 0169-409X

VL - 194

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

M1 - 114722

ER -

Mechanotherapy in oncology: Targeting nuclear mechanics and mechanotransduction

Abstract

UN SDGs

Keywords

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