Mechano-assisted strategies to improve cancer chemotherapy

Shanshan Zhu; Guorui Jin; Xiaocong He; Yuan Li; Feng Xu; Hui Guo

doi:10.1016/j.lfs.2024.123178

Mechano-assisted strategies to improve cancer chemotherapy

Shanshan Zhu
, Guorui Jin
, Xiaocong He
, Yuan Li
, Feng Xu
, Hui Guo

School of Life Science and Technology (SLST)

Xi'an Jiaotong University
The Second Affiliated Hospital of Xi'an Jiaotong University

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Chemotherapy remains a cornerstone in cancer treatment; however, its effectiveness is frequently undermined by the development of drug resistance. Recent studies underscores the pivotal role of the tumor mechanical microenvironment (TMME) and the emerging field of mechanical nanomedicine in tackling chemo-resistance. This review offers an in-depth analysis of mechano-assisted strategies aimed at mitigating chemo-resistance through the modification of the TMME and the refinement of mechanical nanomedicine delivery systems. We explore the potential of targeting abnormal tumor mechanical properties as a promising avenue for enhancing the efficacy of cancer chemotherapy, which offers novel directions for advancing future cancer therapies, especially from the mechanomedicine perspective.

Original language	English
Article number	123178
Journal	Life Sciences
Volume	359
DOIs	https://doi.org/10.1016/j.lfs.2024.123178
State	Published - 15 Dec 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chemo-resistance
Nanomedicine mechanical properties
Tumor mechanical microenvironment

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10.1016/j.lfs.2024.123178

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title = "Mechano-assisted strategies to improve cancer chemotherapy",

abstract = "Chemotherapy remains a cornerstone in cancer treatment; however, its effectiveness is frequently undermined by the development of drug resistance. Recent studies underscores the pivotal role of the tumor mechanical microenvironment (TMME) and the emerging field of mechanical nanomedicine in tackling chemo-resistance. This review offers an in-depth analysis of mechano-assisted strategies aimed at mitigating chemo-resistance through the modification of the TMME and the refinement of mechanical nanomedicine delivery systems. We explore the potential of targeting abnormal tumor mechanical properties as a promising avenue for enhancing the efficacy of cancer chemotherapy, which offers novel directions for advancing future cancer therapies, especially from the mechanomedicine perspective.",

keywords = "Chemo-resistance, Nanomedicine mechanical properties, Tumor mechanical microenvironment",

author = "Shanshan Zhu and Guorui Jin and Xiaocong He and Yuan Li and Feng Xu and Hui Guo",

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year = "2024",

month = dec,

day = "15",

doi = "10.1016/j.lfs.2024.123178",

language = "英语",

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TY - JOUR

T1 - Mechano-assisted strategies to improve cancer chemotherapy

AU - Zhu, Shanshan

AU - Jin, Guorui

AU - He, Xiaocong

AU - Li, Yuan

AU - Xu, Feng

AU - Guo, Hui

PY - 2024/12/15

Y1 - 2024/12/15

N2 - Chemotherapy remains a cornerstone in cancer treatment; however, its effectiveness is frequently undermined by the development of drug resistance. Recent studies underscores the pivotal role of the tumor mechanical microenvironment (TMME) and the emerging field of mechanical nanomedicine in tackling chemo-resistance. This review offers an in-depth analysis of mechano-assisted strategies aimed at mitigating chemo-resistance through the modification of the TMME and the refinement of mechanical nanomedicine delivery systems. We explore the potential of targeting abnormal tumor mechanical properties as a promising avenue for enhancing the efficacy of cancer chemotherapy, which offers novel directions for advancing future cancer therapies, especially from the mechanomedicine perspective.

AB - Chemotherapy remains a cornerstone in cancer treatment; however, its effectiveness is frequently undermined by the development of drug resistance. Recent studies underscores the pivotal role of the tumor mechanical microenvironment (TMME) and the emerging field of mechanical nanomedicine in tackling chemo-resistance. This review offers an in-depth analysis of mechano-assisted strategies aimed at mitigating chemo-resistance through the modification of the TMME and the refinement of mechanical nanomedicine delivery systems. We explore the potential of targeting abnormal tumor mechanical properties as a promising avenue for enhancing the efficacy of cancer chemotherapy, which offers novel directions for advancing future cancer therapies, especially from the mechanomedicine perspective.

KW - Chemo-resistance

KW - Nanomedicine mechanical properties

KW - Tumor mechanical microenvironment

UR - https://www.scopus.com/pages/publications/85207805565

U2 - 10.1016/j.lfs.2024.123178

DO - 10.1016/j.lfs.2024.123178

M3 - 文献综述

C2 - 39471901

AN - SCOPUS:85207805565

SN - 0024-3205

VL - 359

JO - Life Sciences

JF - Life Sciences

M1 - 123178

ER -

Mechano-assisted strategies to improve cancer chemotherapy

Abstract

UN SDGs

Keywords

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