Mechanisms of resistance to RAF inhibitors in melanoma

Andrew E. Aplin; Fred M. Kaplan; Yongping Shao

doi:10.1038/jid.2011.147

Mechanisms of resistance to RAF inhibitors in melanoma

Andrew E. Aplin
, Fred M. Kaplan
, Yongping Shao

Thomas Jefferson University

Research output: Contribution to journal › Review article › peer-review

74 Scopus citations

Abstract

The recent RAF inhibitor trial with PLX4032/RG7204 in late-stage mutant B-RAF melanoma patients has been lauded as a success story for personalized cancer therapy since short-term clinical responses were observed in the majority of patients. However, initial responses were followed by subsequent tumor re-growth, and a subset of patients showed intrinsic resistance. Bi-directional translational efforts are now essential to determine the mechanisms underlying acquired/secondary and intrinsic resistance to RAF inhibitors.

Original language	English
Pages (from-to)	1817-1820
Number of pages	4
Journal	Journal of Investigative Dermatology
Volume	131
Issue number	9
DOIs	https://doi.org/10.1038/jid.2011.147
State	Published - Sep 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/jid.2011.147

Cite this

@article{440a43934ac94629ba95cfe6466e1d74,

title = "Mechanisms of resistance to RAF inhibitors in melanoma",

abstract = "The recent RAF inhibitor trial with PLX4032/RG7204 in late-stage mutant B-RAF melanoma patients has been lauded as a success story for personalized cancer therapy since short-term clinical responses were observed in the majority of patients. However, initial responses were followed by subsequent tumor re-growth, and a subset of patients showed intrinsic resistance. Bi-directional translational efforts are now essential to determine the mechanisms underlying acquired/secondary and intrinsic resistance to RAF inhibitors.",

author = "Aplin, \{Andrew E.\} and Kaplan, \{Fred M.\} and Yongping Shao",

year = "2011",

month = sep,

doi = "10.1038/jid.2011.147",

language = "英语",

volume = "131",

pages = "1817--1820",

journal = "Journal of Investigative Dermatology",

issn = "0022-202X",

publisher = "Elsevier B.V.",

number = "9",

}

TY - JOUR

T1 - Mechanisms of resistance to RAF inhibitors in melanoma

AU - Aplin, Andrew E.

AU - Kaplan, Fred M.

AU - Shao, Yongping

PY - 2011/9

Y1 - 2011/9

N2 - The recent RAF inhibitor trial with PLX4032/RG7204 in late-stage mutant B-RAF melanoma patients has been lauded as a success story for personalized cancer therapy since short-term clinical responses were observed in the majority of patients. However, initial responses were followed by subsequent tumor re-growth, and a subset of patients showed intrinsic resistance. Bi-directional translational efforts are now essential to determine the mechanisms underlying acquired/secondary and intrinsic resistance to RAF inhibitors.

AB - The recent RAF inhibitor trial with PLX4032/RG7204 in late-stage mutant B-RAF melanoma patients has been lauded as a success story for personalized cancer therapy since short-term clinical responses were observed in the majority of patients. However, initial responses were followed by subsequent tumor re-growth, and a subset of patients showed intrinsic resistance. Bi-directional translational efforts are now essential to determine the mechanisms underlying acquired/secondary and intrinsic resistance to RAF inhibitors.

UR - https://www.scopus.com/pages/publications/80051794730

U2 - 10.1038/jid.2011.147

DO - 10.1038/jid.2011.147

M3 - 文献综述

AN - SCOPUS:80051794730

SN - 0022-202X

VL - 131

SP - 1817

EP - 1820

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 9

ER -

Mechanisms of resistance to RAF inhibitors in melanoma

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this