Machine perfusion versus cold storage of livers: a meta-analysis

Sushun Liu; Qing Pang; Jingyao Zhang; Mimi Zhai; Sinan Liu; Chang Liu

doi:10.1007/s11684-016-0474-7

Machine perfusion versus cold storage of livers: a meta-analysis

Sushun Liu
, Qing Pang
, Jingyao Zhang
, Mimi Zhai
, Sinan Liu
, Chang Liu

Health Science Center

Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Different organ preservation methods are key factors influencing the results of liver transplantation. In this study, the outcomes of experimental models receiving donation after cardiac death (DCD) livers preserved through machine perfusion (MP) or static cold storage (CS) were compared by conducting a meta-analysis. Standardized mean difference (SMD) and 95% confidence interval (CI) were calculated to compare pooled data from two animal species. Twenty-four studies involving MP preservation were included in the meta-analysis. Compared with CS preservation, MP can reduce the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and hyaluronic acid (HA) and the changes in liver weight. By contrast, MP can enhance bile production and portal vein flow (PVF). Alkaline phosphatase (ALP) levels and histological changes significantly differed between the two preservation methods. In conclusion, MP of DCD livers is superior to CS in experimental animals.

Original language	English
Pages (from-to)	451-464
Number of pages	14
Journal	Frontiers of Medicine
Volume	10
Issue number	4
DOIs	https://doi.org/10.1007/s11684-016-0474-7
State	Published - 1 Dec 2016

Keywords

DCD
cold storage
machine perfusion
meta-analysis

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10.1007/s11684-016-0474-7

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title = "Machine perfusion versus cold storage of livers: a meta-analysis",

abstract = "Different organ preservation methods are key factors influencing the results of liver transplantation. In this study, the outcomes of experimental models receiving donation after cardiac death (DCD) livers preserved through machine perfusion (MP) or static cold storage (CS) were compared by conducting a meta-analysis. Standardized mean difference (SMD) and 95\% confidence interval (CI) were calculated to compare pooled data from two animal species. Twenty-four studies involving MP preservation were included in the meta-analysis. Compared with CS preservation, MP can reduce the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and hyaluronic acid (HA) and the changes in liver weight. By contrast, MP can enhance bile production and portal vein flow (PVF). Alkaline phosphatase (ALP) levels and histological changes significantly differed between the two preservation methods. In conclusion, MP of DCD livers is superior to CS in experimental animals.",

keywords = "DCD, cold storage, machine perfusion, meta-analysis",

author = "Sushun Liu and Qing Pang and Jingyao Zhang and Mimi Zhai and Sinan Liu and Chang Liu",

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doi = "10.1007/s11684-016-0474-7",

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T1 - Machine perfusion versus cold storage of livers

T2 - a meta-analysis

AU - Liu, Sushun

AU - Pang, Qing

AU - Zhang, Jingyao

AU - Zhai, Mimi

AU - Liu, Sinan

AU - Liu, Chang

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Different organ preservation methods are key factors influencing the results of liver transplantation. In this study, the outcomes of experimental models receiving donation after cardiac death (DCD) livers preserved through machine perfusion (MP) or static cold storage (CS) were compared by conducting a meta-analysis. Standardized mean difference (SMD) and 95% confidence interval (CI) were calculated to compare pooled data from two animal species. Twenty-four studies involving MP preservation were included in the meta-analysis. Compared with CS preservation, MP can reduce the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and hyaluronic acid (HA) and the changes in liver weight. By contrast, MP can enhance bile production and portal vein flow (PVF). Alkaline phosphatase (ALP) levels and histological changes significantly differed between the two preservation methods. In conclusion, MP of DCD livers is superior to CS in experimental animals.

AB - Different organ preservation methods are key factors influencing the results of liver transplantation. In this study, the outcomes of experimental models receiving donation after cardiac death (DCD) livers preserved through machine perfusion (MP) or static cold storage (CS) were compared by conducting a meta-analysis. Standardized mean difference (SMD) and 95% confidence interval (CI) were calculated to compare pooled data from two animal species. Twenty-four studies involving MP preservation were included in the meta-analysis. Compared with CS preservation, MP can reduce the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and hyaluronic acid (HA) and the changes in liver weight. By contrast, MP can enhance bile production and portal vein flow (PVF). Alkaline phosphatase (ALP) levels and histological changes significantly differed between the two preservation methods. In conclusion, MP of DCD livers is superior to CS in experimental animals.

KW - DCD

KW - cold storage

KW - machine perfusion

KW - meta-analysis

UR - https://www.scopus.com/pages/publications/84994779242

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DO - 10.1007/s11684-016-0474-7

M3 - 文章

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SN - 2095-0217

VL - 10

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JO - Frontiers of Medicine

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IS - 4

ER -

Machine perfusion versus cold storage of livers: a meta-analysis

Abstract

Keywords

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