TY - JOUR
T1 - Lethal (2) giant larvae
T2 - An indispensable regulator of cell polarity and cancer development
AU - Cao, Fang
AU - Miao, Yi
AU - Xu, Kedong
AU - Liu, Peijun
N1 - Publisher Copyright:
© 2015 Ivyspring International Publisher.
PY - 2015/2/15
Y1 - 2015/2/15
N2 - Cell polarity is one of the most basic properties of all normal cells and is essential for regulating numerous biological processes. Loss of polarity is considered a hallmark for cancer. Multiple polarity proteins are implicated in maintenance of cell polarity. Lethal (2) giant larvae (Lgl) is one of polarity proteins that plays an important role in regulating cell polarity, asymmetric division as well as tumorigenesis. Lgl proteins in different species have similar structures and conserved functions. Lgl acts as an indispensable regulator of cell biological function, including cell polarity and asymmetric division, through interplaying with other polarity proteins, regulating exocytosis, mediating cytoskeleton and being involved in signaling pathways. Furthermore, Lgl plays a role of a tumor suppressor, and the aberrant expression of Hugl, a human homologue of Lgl, contributes to multiple cancers. However, the exact functions of Lgl and the underlying mechanisms remain enigmatic. In this review, we will give an overview of the Lgl functions in cell polarity and cancer development, discuss the potential mechanisms underlying these functions, and raise our conclusion of previous studies and points of view about the future studies.
AB - Cell polarity is one of the most basic properties of all normal cells and is essential for regulating numerous biological processes. Loss of polarity is considered a hallmark for cancer. Multiple polarity proteins are implicated in maintenance of cell polarity. Lethal (2) giant larvae (Lgl) is one of polarity proteins that plays an important role in regulating cell polarity, asymmetric division as well as tumorigenesis. Lgl proteins in different species have similar structures and conserved functions. Lgl acts as an indispensable regulator of cell biological function, including cell polarity and asymmetric division, through interplaying with other polarity proteins, regulating exocytosis, mediating cytoskeleton and being involved in signaling pathways. Furthermore, Lgl plays a role of a tumor suppressor, and the aberrant expression of Hugl, a human homologue of Lgl, contributes to multiple cancers. However, the exact functions of Lgl and the underlying mechanisms remain enigmatic. In this review, we will give an overview of the Lgl functions in cell polarity and cancer development, discuss the potential mechanisms underlying these functions, and raise our conclusion of previous studies and points of view about the future studies.
KW - Asymmetric division
KW - Cell polarity
KW - Lethal (2) giant larvae
KW - Tumor suppression
UR - https://www.scopus.com/pages/publications/84928802153
U2 - 10.7150/ijbs.11243
DO - 10.7150/ijbs.11243
M3 - 文献综述
C2 - 25798058
AN - SCOPUS:84928802153
SN - 1449-2288
VL - 11
SP - 380
EP - 389
JO - International Journal of Biological Sciences
JF - International Journal of Biological Sciences
IS - 4
ER -
