Laparoscopic excision of a fallopian tube teratoma with multiple uterine leiomyomas and an allelic p53 mutation: A case report

BACKGROUND: Most teratomas are benign and can be removed by surgery, but the gene mutations in teratomas are seldom reported. CASE: A 35-year-old wom-an was diagnosed with a fal- lopian tube teratoma mixed with multiple uterine leio- myomas. The right salpingec- tomy was performed; bipolar electric coagulation was taken from the right oviduct umbrella end to the uterus angle to remove the right fallopian tube. The specimen was removed, and grease-like liquid and hair were observed after the sac wall was cut. A number of blue- purple endometriosis lesions were observed at the rear body of the uterus and Douglas nests. Frozen sections were made from the right fallopian tube with benign cyst teratoma. Histopathological examination showed mature cartilage tissues, well-differentiated squamous epithelia and sebaceous glands, and fibrous adipose tissues. Although fallopian tube tissues appeared benign, an allelic mutation of p53 was found at the nucleotide 469, which resulted in amino acid mutation from valine to phe- nylalanine. The patient re- covered without reproductive obstacles and was pregnant after 8 months. The potential genetic alteration and possible mechanism of teratomas are discussed. CONCLUSION: This is the first reported teratoma case carrying a p53 mutation in a woman who later became pregnant and delivered a healthy infant after successful surgery.