Abstract
Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene transcription via lactylation of histones and non-histone proteins, i.e., a novel posttranslational modification. This review summarizes recent advances related to lactylation in lactate metabolism and diseases. Notably, lactylation plays a vital role in cancer, inflammation, and regeneration; however, the specific mechanism remains unclear. Histone lactylation regulates oncogenic processes by targeting gene transcription and inflammation via macrophage activation. Eventually, we identified research gaps and recommended several primary directions for further studies.
| Original language | English |
|---|---|
| Pages (from-to) | 1419-1429 |
| Number of pages | 11 |
| Journal | Inflammation |
| Volume | 45 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 2022 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- cancer
- gene transcription
- inflammation
- lactate
- lactylation
- posttranslational modification
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